Table 4.

Cytotoxic activity of methanol and dichloromethane extracts of the aerial parts of sea heath (F. laevis) towards human hepatocarcinoma (HepG2) and mouse bone marrow stromal (S17) cell lines. The results are expressed as half-maximal effective concentration (EC₅₀) values (µg/mL).

Cell Line	Methanol	Dichloromethane	Positive Control
HepG2	>100 µg/mL	52.1 ± 2.5 b (SI > 1.9)	1.45 ± 0.15 a
S17	>100 µg/mL	>100 µg/mL	7.86 ± 0.25

Values represent the mean ± standard error of the mean (SEM) of at least three experiments, each performed in triplicate (n = 9). In the same line, values followed by different letters (a, b) are significantly different at p < 0.05 (Student’s t-test). SI: selectivity index. Positive control: etoposide.