Table 2.

Siponimod Titration protocol⁴⁸ *

Titration for a Maintenance Dose of 1 mg/day (CYP2C9 *1/*3, *2/*3)	Titration for a Maintenance Dose of 1mg/day (CYP2C9 *1/*1, *1/*2, *2/*2)
Day 1: 0.25 mg/day	Day 1: 0.25 mg/day
Day 2: 0.25 mg/day	Day 2: 0.25 mg/day
Day 3: 0.5 mg/day	Day 3: 0.5 mg/day
Day 4: 0.75 mg/day	Day 4: 0.75 mg/day
Day 5 and thereafter: 1 mg/day	Day 5: 1.25 mg/day
	Day 6 and thereafter: 2 mg/day

Notes: *If a dose is missed during the initiation protocol, the dosage titration should be restarted. However, in the maintenance period, repeat dosage titration is not needed for drug discontinuation of <4 consecutive days.^38,48.