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. 2022 Jan 30;2022:1315299. doi: 10.1155/2022/1315299

Table 2.

Effect of topical medication on corneal endothelial cell density (CECD).

% mean cell CECD change at 1 year to baseline (SD) Number of patients Citation
Prostaglandin analogues
 Latanoprost 0.3 (2.2) 127 [86]
−2.3 18 [87]
−3.2 (6 months) 54 [88]
−0.04 (3 months) 146 [85]

Carbonic anhydrase inhibitor
 Dorzolamide No significant difference [79]
0.2 7 [78]
−3.6 (5.0) 148 [83]

Beta blocker
 Timolol −4.5 (4.2) 72 [83]
0.1 (1.8) 126 [86]
 Betoxalol −4.2 (3.6) 78 [83]

Rho Kinase Inhibitor
 Netarsudil 0.02% 0.6 (3 months) 143 [85]

Combined therapy
 Latanoprost-timolol 0 (2.5) 126 [86]
 Latanoprost-brinzolamide −0.6 16 [87]
 Netarsudil 0.02%/latanoprost 0.6 (3 months) 126 [85]
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