Table 2.

Effect of topical medication on corneal endothelial cell density (CECD).

	% mean cell CECD change at 1 year to baseline (SD)	Number of patients	Citation
Prostaglandin analogues
Latanoprost	0.3 (2.2)	127	[86]
	−2.3	18	[87]
	−3.2 (6 months)	54	[88]
	−0.04 (3 months)	146	[85]
Carbonic anhydrase inhibitor
Dorzolamide	No significant difference		[79]
	0.2	7	[78]
	−3.6 (5.0)	148	[83]
Beta blocker
Timolol	−4.5 (4.2)	72	[83]
	0.1 (1.8)	126	[86]
Betoxalol	−4.2 (3.6)	78	[83]
Rho Kinase Inhibitor
Netarsudil 0.02%	0.6 (3 months)	143	[85]
Combined therapy
Latanoprost-timolol	0 (2.5)	126	[86]
Latanoprost-brinzolamide	−0.6	16	[87]
Netarsudil 0.02%/latanoprost	0.6 (3 months)	126	[85]