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. 2022 Mar 21;59(6):3402–3413. doi: 10.1007/s12035-022-02793-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Comparison of [¹⁸F]PI-2620 PET, ex vivo autoradiography and histology. Shown are sagittal sections of the same mouse (11 months old), rostral = left. (A) [¹⁸F]PI-2620 PET, start 8 min after tracer injection, 30-min scan duration. Scale bar: 2.5 mm. Color scale: 0–5 SUVR_bg. Tracer accumulation was highest in the olfactory bulb and the frontal cortex. (B) Ex vivo autoradiography of the same animal, start 2 h 15 min after injection, duration 45 min. Smoothing 0.61 mm FWHM. Scale bar: 2.5 mm. Color scale: 0.000–0.0015 cpm. Highest tracer accumulation is visible in the olfactory bulb, frontal cortex, and hippocampus. (C) Histology of the same animal: Thioflavin S staining (green) and PHF1 staining (brown). Scale bars: 30 µm. Tau fibrils are present in the olfactory bulb, frontal cortex, and hippocampus, but absent in the cerebellum. Abbreviations: Cer, cerebellum; FC, frontal cortex; HG, Harderian gland; Hip, hippocampus; OB, olfactory bulb