Table 3.

Clinical numerical variables showing differences between the evaluated comparisons.

Variable	CR + PR vs NR		CR vs NR		PR vs NR		CR vs PR
	p-value	Log2FC	p-value	Log2FC	p-value	Log2FC	p-value	Log2FC
IGF1 diagnosis	0.035	− 0.33	0.007	− 0.47	0.722	− 0.16	0.081	− 0.31
IGF1 index diagnosis	0.051	− 0.41	0.086	− 0.39	0.063	− 0.43	0.838	0.04
GH diagnosis	0.590	1.04	0.134	0.94	0.429	1.17	0.134	− 0.22
GH after OGTT	0.622	1.27	0.728	1.29	0.633	1.25	0.941	0.03
BMI diagnosis	0.094	− 0.13	0.044	− 0.17	0.452	− 0.07	0.316	− 0.10
Maximum diameter	0.178	− 0.27	0.092	− 0.35	0.532	− 0.16	0.708	− 0.19
Age diagnosis	0.197	0.14	0.272	0.13	0.802	− 0.03	0.276	0.16

The clinical numerical variables that were tested: IGF1 levels measured at diagnosis in each center, IGF1 index at diagnosis, GH levels measured at diagnosis in each center, GH levels measured after a 75 g oral glucose load (OGTT), BMI (Body Mass Index) at diagnosis, maximum tumor diameter in the MRI measured in each center and the age of the patient at diagnosis. T-test or Wilcoxon-test p-values are shown. Statistically significant values (p-value < 0.05) are reported in bold, and p-value < 0.1 in italic Log2FC: Log2 Fold Change.