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. 2022 May 28;12:8982. doi: 10.1038/s41598-022-13029-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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mGluR5 ablation promotes hippocampal neuronal loss in aged mice. Graphs show quantification of NeuN-labeled hippocampal neurons per 37,317 μm² in wild-type (WT), BACHD, mGluR5^−/− and BACHD/mGluR5^−/− mice at 2 (n = 8) (A), 6 (n = 8) (B) and 12 (n = 8–10) (C) months of age. (D) Shown are representative images for NeuN immunostaining of hippocampal slices from 12-month-old WT, BACHD, mGluR5^−/− and BACHD/mGluR5^−/− mice. Scale bar = 100 μm. Data represent the means ± SEM obtained from 6 images taken from 2 histological slices per mouse. **p < 0.01 and ***p < 0.001 by one-way ANOVA and Bonferroni's multiple comparisons test.