Figure 15.

Computational design of α-helical toroids. The protocol consists of a) ab initio folding to generate backbone conformations, b) sequence design of conformations, c) filtering to remove poor designs, d) clustering of results to identify recurring packing arrangements, e) resampling of structures from the clusters, and f) a final assessment of results by re-predicting the designed structures from their sequences. Adapted with permission from Ref.¹⁸⁵. Copyright 2015 NPG.