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. Author manuscript; available in PMC: 2022 May 29.
Published in final edited form as: Chem Rev. 2021 Aug 18;121(22):13701–13796. doi: 10.1021/acs.chemrev.1c00308

Figure 16.

Figure 16.

Computational design of cyclic homo-oligomers. a) Monomers are first docked in cyclic geometries using low-resolution, symmetric docking. b) Docked oligomers are then scored using a residue-pair transform (RPX) method which models side-chain interactions implicitly. c) The best scoring geometries are finally subjected to interface design. Adapted with permission from Ref.355. Copyright 2016 NPG.