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. Author manuscript; available in PMC: 2022 May 29.
Published in final edited form as: Chem Rev. 2021 Aug 18;121(22):13701–13796. doi: 10.1021/acs.chemrev.1c00308

Figure 27.

Figure 27.

Design of protein cages by genetic fusion using α-helical peptides as linkers. a) Illustration of the geometric design principle of genetic fusion. Crystal structure of designed 12-mer tetrahedral cage (b) and 24-mer cubic cage (c). Natural oligomers used as building blocks (left) and genetically fused components, assembled into symmetric cage structures (right). (a) Adapted with permission from Ref.376. Copyright 2012 AAAS. (b) Adapted with permission from Ref.376. Copyright 2012 AAAS. (c) Adapted with permission from Ref.378. Copyright 2014 NPG.