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. Author manuscript; available in PMC: 2022 May 29.
Published in final edited form as: Chem Rev. 2021 Aug 18;121(22):13701–13796. doi: 10.1021/acs.chemrev.1c00308

Figure 30.

Figure 30.

Overview of two-component tetrahedral protein cages developed by computational design. a) Symmetric docking of two distinct trimeric proteins to design a tetrahedral cage (T33). Atomic structure (b) and ns-TEM images (c) of T33–15. Two-fold and three-fold views are shown. d) Redesign of protein-protein interfaces between two trimers. e) The T32 cage is constructed with one trimeric and one dimeric building blocks. Crystal structure (f) and ns-TEM results (h) are shown. Insets in (c) and (h) show projections calculated from the computationally designed model (left) and class averages of the particles from microscopy (right). Adapted with permission from Ref.389. Copyright 2014 NPG.