Figure 60.

Computationally designed binary 2D protein arrays. a) Orientation of the D₃ and D₂ symmetric protein building blocks to form a heterogeneous p6m protein assembly (left). Top view of the p6m symmetry operators and the lattice spacing degree of freedom, d (middle). A plausible arrangement of D₃ and D₂ symmetric building blocks to form p6m lattices (right). b) Interface between the two protein building blocks. c) ns-TEM characterization of p6m arrays formed in E.coli upon co-expression of the two protein building blocks. Adapted with permission from Ref.⁴⁸⁹. Copyright 2021 NPG.