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. Author manuscript; available in PMC: 2022 May 29.
Published in final edited form as: Chem Rev. 2021 Aug 18;121(22):13701–13796. doi: 10.1021/acs.chemrev.1c00308

Figure 76.

Figure 76.

Stimuli-responsive, switchable protein assemblies. a) Mg2+-mediated GroELMC nanotube formation and ATP-triggered chemomechanical nanotube scission. b) Thermodynamic model for allosteric assembly of the engineered Cl2 variants controlled by temperature and C-peptide concentration. All the engineered variants populate the same five species: native monomer (N), fold-switched monomer (switch), hexamer (H), dodecamer (H2) and unfolded monomer (U). c) Adenylate kinase (AKe) in open and closed state (left) and structural transition of AKe-based protein amphiphile assembly from 1D nanofilament to 2D rectangular nanosheet upon Ap5A binding. (a) Adapted with permission from Ref.203. Copyright 2013 NPG. (b) Adapted with permission from Ref.363. Copyright 2019 NPG. (c) Adapted with permission from Ref.485. Copyright 2019 ACS.