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. Author manuscript; available in PMC: 2022 May 29.
Published in final edited form as: Chem Rev. 2021 Aug 18;121(22):13701–13796. doi: 10.1021/acs.chemrev.1c00308

Figure 78.

Figure 78.

Allosteric metalloprotein assemblies with strained disulfide bonds. a) Scheme showing structural rearrangements in the Zn-C81/C96RIDC14 (labeled as R1) tetramer upon Zn2+ removal (top) and close-up view of A38-A38 residue pairs (bottom). b) Crystal structures of Zn-C28/C81/C96R14 and the metal-free C28/C81/C96R14 (top); hydrolytic dissociation of a disulfide bond and close-up view of the broken C38-C38 disulfide bond, forming a Cys and Cys sulfenic acid (bottom). Adapted with permission from Ref.232. Copyright 2016 ACS.