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. 2022 May 29;60:151983. doi: 10.1016/j.anndiagpath.2022.151983

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Fig. 5 — Alterations in key intercalated disc proteins in the heart in fatal COVID-19. Panels A and B show the distribution of Na_V1.5 (panel A) and N cadherin plus connexin-43 (co-localization with N cadherin fluorescent green and connexin-43 red) in the normal pre-COVID heart; note the strong localization to the intercalated disc region that is perpendicular to the long axis of the myocyte. Each of the heart tissues from fatal COVID-19 cases showed the baseline pattern for N cadherin (panel C) but each showed substantial marked migration of the Cx43 (panel D with panel E being a normal pre-COVID control) and Na_V1.5 signals (panel F) to the lateral border of the myocyte (rectangles). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)