Table 2.
Local and systemic early adverse events among pregnant women receiving 2 injections of COVID-19 mRNA vaccine.
| Comirnaty Pfizer/BioNTech - BNT162b2 n = 271 |
Moderna - mRNA-1273 n = 623 |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1st dose | 2nd dose | 1st dose | 2nd dose | ||||||||||||||||||||||||||
| n | % | 95% CI | n | % | 95% CI | n | % | 95% CI | n | % | 95% CI | ||||||||||||||||||
| No reaction | 21 | 7.7 | % | 4.9 | - | 11.6 | 25 | 9.2 | % | 6.1 | - | 13.3 | 53 | 8.5 | % | 6.4 | - | 11.0 | 13 | 2.1 | % | 1.1 | - | 3.5 | |||||
| Local reaction | 201 | 74.2 | % | 68.5 | - | 79.3 | 191 | 70.5 | % | 64.7 | - | 75.8 | 526 | 84.4 | % | 81.3 | - | 87.2 | 529 | 84.9 | % | 81.9 | - | 87.6 | |||||
| Pain | 196 | 72.3 | % | 66.6 | - | 77.6 | 182 | 67.2 | % | 61.2 | - | 72.7 | 499 | 80.1 | % | 76.7 | - | 83.2 | 507 | 81.4 | % | 78.1 | - | 84.4 | |||||
| Redness | 5 | 1.8 | % | 0.6 | - | 4.3 | 11 | 4.1 | % | 2.0 | - | 7.1 | 60 | 9.6 | % | 7.4 | - | 12.2 | 89 | 14.3 | % | 11.6 | - | 17.3 | |||||
| Swelling | 10 | 3.7 | % | 1.8 | - | 6.7 | 14 | 5.2 | % | 2.9 | - | 8.5 | 59 | 9.5 | % | 7.3 | - | 12.0 | 85 | 13.6 | % | 11.0 | - | 16.6 | |||||
| Induration | 5 | 1.8 | % | 0.6 | - | 4.3 | 4 | 1.5 | % | 0.4 | - | 3.7 | 32 | 5.1 | % | 3.5 | - | 7.2 | 37 | 5.9 | % | 4.2 | - | 8.1 | |||||
| Warmth | 7 | 2.6 | % | 1.0 | - | 5.2 | 6 | 2.2 | % | 0.8 | - | 4.8 | 24 | 3.9 | % | 2.5 | - | 5.7 | 35 | 5.6 | % | 3.9 | - | 7.7 | |||||
| Itch | 1 | 0.4 | % | 0.0 | - | 2.0 | 3 | 1.1 | % | 0.2 | - | 3.2 | 14 | 2.2 | % | 1.2 | - | 3.7 | 29 | 4.7 | % | 3.1 | - | 6.6 | |||||
| Haematoma | 5 | 1.8 | % | 0.6 | - | 4.3 | 2 | 0.7 | % | 0.1 | - | 2.6 | 7 | 1.1 | % | 0.5 | - | 2.3 | 8 | 1.3 | % | 0.6 | - | 2.5 | |||||
| Other | 0 | 0.0 | % | 0.0 | - | 1.4 | 1 | 0.4 | % | 0.0 | - | 2.0 | 5 | 0.8 | % | 0.3 | - | 1.9 | 4 | 0.6 | % | 0.2 | - | 1.6 | |||||
| Systemic reaction | 82 | 30.3 | % | 24.8 | - | 36.1 | 114 | 42.1 | % | 36.1 | - | 48.2 | 234 | 37.6 | % | 33.7 | - | 41.5 | 488 | 78.3 | % | 74.9 | - | 81.5 | |||||
| Fatigue | 53 | 19.6 | % | 15.0 | - | 24.8 | 80 | 29.5 | % | 24.2 | - | 35.3 | 157 | 25.2 | % | 21.8 | - | 28.8 | 376 | 60.4 | % | 56.4 | - | 64.2 | |||||
| Headache | 28 | 10.3 | % | 7.0 | - | 14.6 | 56 | 20.7 | % | 16.0 | - | 26.0 | 100 | 16.1 | % | 13.3 | - | 19.2 | 285 | 45.7 | % | 41.8 | - | 49.8 | |||||
| Muscle pain | 21 | 7.7 | % | 4.9 | - | 11.6 | 32 | 11.8 | % | 8.2 | - | 16.3 | 72 | 11.6 | % | 9.2 | - | 14.3 | 231 | 37.1 | % | 33.3 | - | 41.0 | |||||
| Joint pain | 7 | 2.6 | % | 1.0 | - | 5.2 | 15 | 5.5 | % | 3.1 | - | 9.0 | 24 | 3.9 | % | 2.5 | - | 5.7 | 157 | 25.2 | % | 21.8 | - | 28.8 | |||||
| Chills | 2 | 0.7 | % | 0.1 | - | 2.6 | 5 | 1.8 | % | 0.6 | - | 4.3 | 14 | 2.2 | % | 1.2 | - | 3.7 | 153 | 24.6 | % | 21.2 | - | 28.1 | |||||
| Fever | 1 | 0.4 | % | 0.0 | - | 2.0 | 4 | 1.5 | % | 0.4 | - | 3.7 | 13 | 2.1 | % | 1.1 | - | 3.5 | 102 | 16.4 | % | 13.6 | - | 19.5 | |||||
| Malaise | 7 | 2.6 | % | 1.0 | - | 5.2 | 10 | 3.7 | % | 1.8 | - | 6.7 | 8 | 1.3 | % | 0.6 | - | 2.5 | 57 | 9.1 | % | 7.0 | - | 11.7 | |||||
| Nausea | 6 | 2.2 | % | 0.8 | - | 4.8 | 6 | 2.2 | % | 0.8 | - | 4.8 | 8 | 1.3 | % | 0.6 | - | 2.5 | 55 | 8.8 | % | 6.7 | - | 11.3 | |||||
| Vomiting | 2 | 0.7 | % | 0.1 | - | 2.6 | 1 | 0.4 | % | 0.0 | - | 2.0 | 5 | 0.8 | % | 0.3 | - | 1.9 | 33 | 5.3 | % | 3.7 | - | 7.4 | |||||
| Other | 11 | 4.1 | % | 2.0 | - | 7.1 | 6 | 2.2 | % | 0.8 | - | 4.8 | 8 | 1.3 | % | 0.6 | - | 2.5 | 32 | 5.1 | % | 3.5 | - | 7.2 | |||||
| Diarrhea | 5 | 1.8 | % | 0.6 | - | 4.3 | 9 | 3.3 | % | 1.5 | - | 6.2 | 8 | 1.3 | % | 0.6 | - | 2.5 | 21 | 3.4 | % | 2.1 | - | 5.1 | |||||