Table 1.
Summary of Antibody Production and Metabolite Changes
| Status | Group | Trend | Metabolites |
|---|---|---|---|
| Metabolites changed before antibody production | Pre-P1Ab vs P1Ab | Upward | I-arabitol, 1-deoxypentitol, Myo-inositol, D-thrtl, Glutarate, GABA, 2hGlutarate, 2-ketoisovalearte, Fatty acids, Cholesterol, Phosphatidylethanolamines, Glutamic acid, BCAAs, Proinflammatory lysoPCs, Glysine, Phosphate, L-cysteine, Acylcarnitine c10:1, Galactosylycerol, Itaconate, Myo-inositol, L-arabitol, SMd42:2, PCp36:2, PCp36:1, PCp34:1, PEp34:1 |
| Downward | Apolipoprotein-A1, lyosophosphatidyl-cholineLPC18:3, SphingomyelinSM (d41:2), Chylomicron transmembrane protein LOC613037, Monopalmitin, L-lysin, D-tagatose, Adrenate, Ceramide c17:5, SMd41:2A, Acylcarnitine C14:2, Adipate, Ribitol, Ceramide c18:1, Ceramide c17:5, Adipate, Ceramided39:1, Ceramided38:1, L-arabitol, Glutamine, Ketoleucine, PC32:0, LPC20:3, LPC20:3, LPL22:6, PEp34:1, SMd39:1, PC39:6, PC38:6, SMd42:2, PC40:8, SMd41:1, PC37:6, TG56:9, SMd41:2A, TG56:8, TG54:5, LPC18:3, TG58:9, PC36:5A, SMd42:2, TG58:10, PC34:2, PC34:3, PC38:5, PC37:6, LPC18:3, PC36:5A, TG58:10, GABA, TG56:9, SMd41:1, SMd41:2A, LPC20:5, PC39:6, SMd39:1, | ||
| Metabolites changed after antibody production | Pre-P1Ab vs P1Ab | Upward | α-Tocopherol, Myo-inositolphosphate, Methionine, Tyrosine, 2-Phenylisopropanol, 3.4,5-Trihydroxypentanoic acid, Taurine, Glycine, Beta-Alanine, Alanine, Serine, 2-Hydroxy-3-methylbutyric acid, Histidine, Ceramides (d18:1/22:6), TG(16:0/18:1/16:0), TG(49:3), TG(50:2), TG(55:2), TG(54:8), TG(54:5), TG(58:10), TG(48:1), TG(14:0/16:0/18:1), TG(51:0), TG(46:1), TG(50:0), TG(52:7), TG(57:0), SM(d18:1/12:0), SM(d36:2), SM(d36:1), SM(d36:0), PC(40:7), PC(40:5), PC(0–42:3), PC(0–40:6), PC(0–38:5), PC(36:5), PC(30:0), PC(40:8), PC(P-20:0/22:4), PC(0–34:2), PC(0–36:2), PC(36:2), PC(0–34:3), PC(36:5), PC(38:6), PC(0–34:3), PC(38:3), PC(36:4), PC(18:2/0:0), PC(18:0/0:0), LPC(18:2), LPC(18:0), LPC(20:3), LysoPC(18:3), PE(34:4e), LC1, LC2, LC3, LC4, LC5, LC7, LC8, LC9, LC12, |
| Downward | Glutamic acid, Aspartic acid, Malic acid, 3,4-Dihydroxybutanoic, Glyceric acid, Ribonic acid, Glycolic acid, L-Threonine, L-Threonic acid, Stigmasterol, Lysine, Tryptophan, Valine, Phenylalanine, α-ketoglutaric acidIsol, leucine, Hydroxyproline, Asparagine, 3-Methylhistidine, 1-Methylhistidine, Proline, LC6, LC10, LC11, PC(18:2/0:0), PC(18:0/0:0), CE(20:4), CE(18:1), CE(20:4), CE(20:5), Carnitine, Ethanolamine |
Note: Pre-PT1Ab represents the status before autoantibody production.
Abbreviation: PT1Ab, patients of antibodies.