Table 2.
Summary of the Age-Specific Metabolites
| Status | Group | Age | Trend | Metabolites |
|---|---|---|---|---|
| Metabolites changed with age | PT1D vs HP | 3m | Upward | Methionine, PC(32:2), PC(34:3), PC(40:4), PC(O-40:4), PC(O-36:2), PC(O-40:5), TG(58:1) |
| Downward | 11-Eicosenoic acid, 1-Monopalmitin, Arachidonic acid, Aspartic acid, D-(-)-Lyxofuranose, D-Arabinose, Glutamic acid, Glyceric acid, Glycolic acid, L-(+)-Threose, L-5-Oxoproline, Leucine, Linoleic acid, Oleic acid, Palmitic acid, Stearic acid, Succinic acid, Tyrosine, CE(20:4), CE(20:5), LPC(16:0), LPC(16:0e), LPC(18:0), LPC(18:2), PC(36:5), TG(14:0/16:0/18:1), TG(18:1/18:1/22:6), TG(51:1), TG(52:7), TG(54:8), TG(56:5), TG(58:10) | |||
| 6m | Upward | 1-Dodecanol, Isoleucine, Leucine, L-Threonine, Methionine, Palmitic acid, Tyrosine, CE(20:4), PC(34:3), PC(36:5), PC(38:5), PC(40:4), PC(O-40:5), TG(14:0/16:0/18:1), TG(18:1/18:1/22:6), TG(51:1), TG(52:1), TG(54:8), TG(56:5) | ||
| Downward | 1,5-Anhydrohexitol, 1-Monopalmitin, Aspartic acid, D-(-)-Lyxofuranose, D-Arabinose, Glutamic acid, Glyceric acid, L-(+)-Threose, L-5-Oxoproline, L-Threonic acid, Pentadecanoic acid, Succinic acid, LPC(18:0), LPC(18:2), TG(52:7), TG(58:1) | |||
| 12m | Upward | 1,5-Anhydrohexitol, Arachidonic acid, Glutamic acid, Glyceric acid, Glycolic acid, Isoleucine, Lactic acid, Leucine, Linoleic acid, L-Threonic acid, Methionine, Stearic acid, Succinic acid, Triethylene glycol, Tyrosine, CE(20:4), CE(20:5), PC(32:2), PC(34:3), PC(36:5), PC(38:5), PC(O-36:2), PC(O-40:5), TG(52:7), TG(54:8) | ||
| Downward | L-(+)-Threose, PC(40:4), TG(14:0/16:0/18:1), TG(18:1/18:1/22:6), TG(51:1) | |||
| 18m | Upward | 11-Eicosenoic acid, D-(-)-Lyxofuranose, Glyceric acid, Isoleucine, Lactic acid, Leucine, Methionine, Triethylene glycol, LPC(18:0), PC(36:5), PC(38:5), PC(O-40:5), TG(56:5), TG(58:1) | ||
| Downward | 1-Monopalmitin, L-Threonic acid, PC(34:3), PC(O-40:4), TG(18:1/18:1/22:6) | |||
| 24m | Upward | 1,5-Anhydrohexitol, 1-Monopalmitin, D-(-)-Lyxofuranose, D-Arabinose, Doconexent, Glyceric acid, Isoleucine, L-(+)-Threose, Linoleic acid, Methionine, Stearic acid, CE(20:5), LPC(18:0), PC(34:3), PC(36:5), PC(38:5), TG(18:1/18:1/22:6), TG(52:7), TG(54:8), TG(58:10) | ||
| Downward | Aspartic acid, L-Threonic acid, L-Threonine, Pentadecanoic acid, PC(40:4), PC(O-40:5), TG(14:0/16:0/18:1), TG(52:1), TG(58:1) | |||
| 36m | Upward | 11-Eicosenoic acid, 1-Dodecanol, 1-Monopalmitin, Arachidonic acid, Doconexent, Glyceric acid, Glycerol monostearate, Lactic acid, Leucine, Linoleic acid, Methionine, Oleic acid, Palmitic acid, Pentadecanoic acid, Pyroglutamic acid, Stearic acid, CE(20:5), LPC(16:0), PC(32:2), PC(34:3), PC(36:5), PC(O-40:5), TG(18:1/18:1/22:6), TG(52:1), TG(52:7), TG(58:10) | ||
| Downward | Aspartic acid, D-Arabinose, Glycolic acid, L-(+)-Threose, PC(38:5), PC(O-36:2), TG(51:1), TG(58:1) | |||
| P1Ab vs HP | 3m | Upward | Doconexent, L-(+)-Threose, Tryptophan, Methionine, Taurine, Proline, Carnitine, 1-Methylhistidine, Beta-Alanine, Tryptophan, alpha-Ketoglutaric acid, 2-Hydroxybutyric acid, 1H-Indole-3-acetic acid, 9-Octadecenoic acid, Maltose, 9.12-Octadecadienoic acid, Tetradecanoic acid, L-Isoleucine, L-Leucine | |
| Downward | 11-Eicosenoic acid, 1-Monopalmitin, 4-Hydroxyphenyllactic, D-(-)-Lyxofuranose, Glutamic acid, Glyceric acid, Pentadecanoic acid, Ribonic, Hydroxyproline, Histidine, Asparagine, 3-Methylhistidine, Arginine, Glycine, Ethanolamine, Threonine, Alanine, Ornithine, Lysine, Valine, Phenylalanine, Succinic acid, Inositol, L-idofuranose, D-Xylose, Butylated Hydroxytoluene, Tyramine, L-Threonine, L-Glutamine, CE(20:4), CE(20:5), LPC(16:0e), LPC(18:2), PC(34:3), PC(31:0), PC(36:5), PC(36:4), PC(37:4), PC(38:3), PE(36:4), TG(14:0/16:0/18:1), TG(16:0/18:0/18:1), TG(51:1), TG(52:1), TG(52:7), TG(54:8), TG(56:5), TG(58:10), Cer(d18:1/22:0), PC(18:2/18:2), TG(42:0), TG(16:0/14:0:16:0), TG(18:1/16:0/12:0), TG(16:0/16:0/16:0), TG(18:1/14:0/16:0), TG(16:0/18:1/15:0), TG(16:1/16:1/18:1), TG(17:0/18:1/18:2), TG(18:1/18:1/18:1), TG(18:2/18:1/18:1) | |||
| 6m | Upward | Alpha-Ketoglutaric acid, 2-Hydroxybutyric acid, 1H-Indole-3 acetic acid, 9-Octadecenoic acid, Mactose, 9.12-Octadecadienoic acid, Tetradecanoic acid, L-Isoleucine, L-Leucine, Taurine, Proline, Carnitine, 1-Methylhistidine, Beta-Alanine, Tryptophan, Methionine, LPC(16:0e), PC(34:3), PC(38:5), PE(36:4), TG(14:0/16:0/18:1), TG(16:0/18:0/18:1), TG(52:1), TG(56:5) | ||
| Downward | Hydroxyproline, Histidine, Asparagine, 3-Methylhistidine, Arginine, Glycine, Ethanolamine, Threonine, Alanine, Ornithine, Lysine, Valine, Phenylalanine, 11-Eicosenoic acid, 1-Monopalmitin, 4-Hydroxyphenyllactic, D-(-)-Lyxofuranose, Pentadecanoic acid, Glutamic acid, Glyceric acid, Glycerol monostearate, L-(+)-Threose, Ribonic, Cer(d18:1/22:0), PC(18:2/18:2), CE(20:5), TG(42:0), TG(16:0/14:0:16:0), TG(18:1/16:0/12:0), TG(16:0/16:0/16:0), TG(18:1/14:0/16:0), TG(16:0/18:1/15:0), TG(16:1/16:1/18:1), TG(17:0/18:1/18:2), TG(18:1/18:1/18:1), TG(18:2/18:1/18:1), TG(52:7), TG(58:10), PC(31:0), PC(36:5) | |||
| 12m | Upward | Alpha-Ketoglutaric acid, 2-Hydroxybutyric acid, 1H-Indole-3 acetic acid, 9-Octadecenoic acid, Mactose, 9.12-Octadecadienoic acid, Tetradecanoic acid, L-Isoleucine, L-Leucine, Taurine, Proline, Carnitine, 1-Methylhistidine, Beta-Alanine, Tryptophan, 1-Dodecanol, Doconexent, Glutamic acid, Glyceric acid, Methionine, Pentadecanoic acid, LPC(16:0e), LPC(18:2), PC(38:3), TG(14:0/16:0/18:1), TG(16:0/18:0/18:1), TG(51:1), TG(58:1) | ||
| Downward | 11-Eicosenoic acid, L-(+)-Threose, Ribonic, Hydroxyproline, Histidine, Asparagine, 3-Methylhistidine, Arginine, Glycine, Ethanolamine, Threonine, Alanine, Ornithine, Lysine, Valine, Phenylalanine, Cer(d18:1/22:0), PC(18:2/18:2), PC(34:3), PC(36:5), TG(42:0), TG(16:0/14:0:16:0), TG(18:1/16:0/12:0), TG(16:0/16:0/16:0), TG(18:1/14:0/16:0), TG(52:1), TG(16:0/18:1/15:0), TG(58:10), TG(54:8), TG(16:1/16:1/18:1), TG(17:0/18:1/18:2), TG(18:1/18:1/18:1), TG(18:2/18:1/18:1), TG(52:7), CE(20:5) | |||
| 18m | Upward | 11-Eicosenoic acid, 4-Hydroxyphenyllactic, D-(-)-Lyxofuranose, Taurine, Proline, L-(+)-Threose, Glutamic acid, Glyceric acid, Carnitine, 1-Methylhistidine, Beta-Alanine, Tryptophan, Ribonic, 2-Hydroxybutyric acid, Ribose, Mactose, Inositol, Butylated Hydroxytoluene, L-Threonine, CE(20:4), PC(31:0), PC(36:5), PC(36:4), PC(37:4), PC(38:3), PC(38:5), TG(54:8), PE(36:4), TG(56:5), TG(58:10) | ||
| Downward | Hydroxyproline, Histidine, Asparagine, 3-Methylhistidine, Arginine, Glycine, Ethanolamine, Threonine, Alanine, Ornithine, Lysine, Valine, Phenylalanine, Cer(d18:1/22:0), TG(42:0), TG(16:0/14:0:16:0), TG(18:1/16:0/12:0), TG(16:0/16:0/16:0), TG(16:0/18:1/15:0), TG(16:1/16:1/18:1), TG(17:0/18:1/18:2), TG(18:2/18:1/18:1) | |||
| 24m | Upward | 11-Eicosenoic acid, 1-Monopalmitin, D-(-)-Lyxofuranose, L-(+)-Threose, Tryptophan, Taurine, Proline, Methionine, Carnitine, 1-Methylhistidine, Beta-Alanine, Tryptophan, 2-Hydroxybutyric acid, Ribose, Mactose, Inositol, Butylated Hydroxytoluene, L-Threonine, PC(31:0), PC(36:5), PC(34:3), PC(36:4), PC(37:4), PC(38:3), PC(38:5), PE(36:4), TG(54:8), TG(56:5), TG(58:10), CE(20:5), TG(14:0/16:0/18:1) | ||
| Downward | Hydroxyproline, Histidine, Asparagine, 3-Methylhistidine, Arginine, Glycine, Ethanolamine, Threonine, Alanine, Ornithine, Lysine, Valine, Phenylalanine, 1-Dodecanol, Glutamic acid, Pentadecanoic acid, Ribonic, LPC(16:0e), LPC(18:2), PC(36:4), PE(36:4), TG(52:1), TG(52:7), TG(56:5), TG(58:1), TG(16:0/18:1/15:0), TG(17:0/18:1/18:2), TG(18:2/18:1/18:1) | |||
| 36m | Upward | 11-Eicosenoic acid, 1-Dodecanol, Glycerol monostearate, Methionine, Pentadecanoic acid, Succinic acid, D-Xylose, Tyramine, L-Isoleucine, L-Leucine, CE(20:4), CE(20:5), PC(36:5), PC(37:4), TG(52:1), TG(52:7), TG(52:7) | ||
| Downward | 4-Hydroxyphenyllactic, D-(-)-Lyxofuranose, Glutamic acid, Tryptophan, Ribonic, L-Tyrosine, 2-Hydroxybutyric acid, Ribose, 1H-Indole-3 acetic acid, 9.12-Octadecadienoic acid, D-Galactofuranose, Glucopyranose, D-Glucuronic acid, L-idofuranose, L-Threonine, L-Glutamine, Creatinine, LPC(16:0e), LPC(18:2), PC(34:3), PC(38:5), PE(36:4), TG(14:0/16:0/18:1), TG(16:0/18:0/18:1), TG(51:1), TG(58:1), TG(42:0), TG(16:0/14:0:16:0), TG(18:1/16:0/12:0), TG(16:0/16:0/16:0), TG(16:0/18:1/15:0), TG (17:0/18:1/18:2), TG(18:2/18:1/18:1) | |||
| 4y | Upward | Alpha-Ketoglutaric acid, 1H-Indole-3 acetic acid, 9.12-Octadecadienoic acid, Inositol, D-Galactofuranose, Butylated Hydroxytoluene, L-Glutamine, Creatinine, | ||
| Downward | L-Tyrosine, Ribose, Succinic acid, 9-Octadecenoic acid, Mactose, L-idofuranose, D-Xylose, Tetradecanoic acid, L-Isoleucine, L-Leucine, TG(42:0), TG(16:0/14:0:16:0), TG(18:1/16:0/12:0), TG(16:0/16:0/16:0), TG(18:1/14:0/16:0), TG(16:0/18:1/15:0), TG(16:1/16:1/18:1), TG (17:0/18:1/18:2), TG(18:2/18:1/18:1) | |||
| 5y | Upward | L-Tyrosine, Ribose, Succinic acid, 9-Octadecenoic acid, Mactose, 9.12-Octadecadienoic acid, D-Galactofuranose, Glucopyranose, D-Glucuronic acid, L-idofuranose, L-Leucine, PC(18:2/18:2), TG(18:1/14:0/16:0) | ||
| Downward | 2-Hydroxybutyric acid, 1H-Indole-3 acetic acid, Inositol, D-Xylose, Tetradecanoic acid, L-Isoleucine, L-Glutamine, Creatinine, | |||
| 6y | Upward | 2-Hydroxybutyric acid, Glucopyranose, L-idofuranose, Tetradecanoic acid, L-Leucine, Creatinine, TG(42:0), TG(16:0/14:0:16:0), TG(18:1/16:0/12:0), TG(16:0/16:0/16:0), TG(18:1/14:0/16:0), TG(16:0/18:1/15:0), TG(18:1/18:1/18:1) | ||
| Downward | Alpha-Ketoglutaric acid, L-Tyrosine, Ribose, 1H-Indole-3 acetic acid, Succinic acid, Inositol, Tyramine, L-Glutamine, PC(18:2/18:2) |
Abbreviations: HP, healthy population; PT1Ab, patients with antibodies; m, months; y, years old.