Table 3.
Demographic, clinical presentation, length of the hospital stay, and outcome of neonates with MIS-N [4, 5, 14, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28]
| Author/[ref] country/N | Type of study | Sex | Age presented | Mode of birth | Gestational age | Clinical manifestation | ICU length of stay | Outcome | Diagnosis |
|---|---|---|---|---|---|---|---|---|---|
| More et al. [14] (India) N = 12 | Case series | F:M = 8:4 | 1–7 days: 6/12 7–28 days: 6/12 | V/CS: 5/7 | Term = 9 Late preterm (32–37 wk) = 3 | Fever 6/12, respiratory-6/12, CVS 6/20, GI manifestations-8/12, haematological 3/12, neurological 1/12 | 5 days to 11 week | Death-2 Survived-10 | Confirmed MIS-N in 7 Suspected MIS-N in 5 |
|
| |||||||||
| Pawar et al. [16] (India) N = 20 | Case series | F:M = 10:10 | 1–5 days | V/CS: 13/7 | Term = 3, late preterm (34–37 wk) = 13, less than 33 wk = 4 | Fever 2/20, respiratory 11/20, CVS 18/20, GIT 6/20, renal 1/20, haematological 2/20, neurological 2/20, cutaneous 1/20 | 7–36 days | Death-2 Survived-18 | Confirmed MIS-N in 2 (duration of fever is not mentioned, appearance on day 1 of life) Suspected MIS-N in 18 |
|
| |||||||||
| Shaiba et al. [17] (KSA) N = 1 | Case series | F | 30 days | NA | NA | Fever, respiratory, CVS, GIT, renal, haematological | 15 days | Death | Confirmed MIS-N |
|
| |||||||||
| Borkotoky et al. [5] (India) N = 1 | Case report | M | 4 h | CS | 38 3/7 | Fever, respiratory, CVS, GIT, haematological, cutaneous | 34 days | Survived | Confirmed MIS-N |
|
| |||||||||
| Diggikar et al. [18] (India) N = 1 | Case report | NA | 7 days | NA | Term | Fever, CVS, neurological | NA | Survived | Confirmed MIS-N |
|
| |||||||||
| Divekar et al. [19] (USA) N = 1 | Case report | F | 1 day | CS | 30 wk | Respiratory, CVS, liver, renal, haematological | 2 months (mostly due to premature) | Survived | Suspected MIS-N |
|
| |||||||||
| Diwakar et al. [20] (India) N = 1 | Case report | M | 19 days | CS | 39 wk | Fever, GIT, haematological, cutaneous | 6 days | Survived | Confirmed MIS-N |
|
| |||||||||
| Eghbalian et al. [21] (Iran) N = 1 | Case report | M | 9 days | CS | 39 wk | Fever, respiratory, GIT: Yes, haematological | 4 days | Survived | Suspected MIS-N (did not specify the duration of fever) |
|
| |||||||||
| Kappanavil et al. [22] (India) N = 1 | Case report | F | 24 days | V | Term | Respiratory, CVS Liver, renal, cutaneous | 20 days | Survived | Suspected MIS-N |
|
| |||||||||
| Lima et al. [23] (Brazil) N = 1 | Case report | F | 1 day | CS | 33 wk | Respiratory, CVS, liver | 22 days | Survived | Suspected MIS-N |
|
| |||||||||
| Magboul et al. [24] (Qatar) N = 1 | Case report | F | 14 days | V | 36+6 wk | Fever, liver, haematological | 14 days | Survived | Suspected MIS-N (duration fever 11 h) |
|
| |||||||||
| McCarty et al. [4] USA N = 1 | Case report | M | 1 day | V | 34+6 wk | Fever, respiratory CVS, haematological | 22 days | Survived | Suspected MIS-N (the neonate became febrile at 12 h of age, and duration is not mentioned) |
|
| |||||||||
| Orlanski-Meyer et al. [25] (Israel) N = 1 | Case report | F | 8 wk | NA | NA | Fever, CVS, GIT, liver, haematological | NA | Survived | Confirmed MIS-N |
|
| |||||||||
| Saha et al. [26] (India) N = 1 | Case report | F | 25 days | NA | Term | Fever, respiratory CVS, GIT, liver, renal, haematological, neurological, cutaneous | 25 days | Survived | Confirmed MIS-N |
|
| |||||||||
| Schoenmakers et al. [27] (Netherlands) N = 1 | Case report | F | 1 day | CS | 31+4 wk GA | Respiratory, CVS, liver, renal, haematological | NA | Survived | Suspected MIS-N (absence of fever) |
|
| |||||||||
| Shaiba et al. [28] (Saudi Arabia) N = 2 | Case report | F | 1 day | V/CS: 1/1 | 36 wk, 32 wk | Respiratory yes in both, CVS yes both Liver yes in 1 case, haematological yes in both | Case 1: 12 days Case 2: 30 days | Both survived | Suspected MIS-N (both) |
F, female; M, male; V, vaginal delivery; CS, caesarean section; CVS, cardiovascular system; GIT, gastrointestinal system; ICU, intensive care unit.