Table 3.
FOT Parameters, FeNO, CAT, ACT and Blood Examination Parameters After Each Treatment
| Run-In | Control | TIO Add-on | P-value | |
|---|---|---|---|---|
| FOT parameters | ||||
| R5 (cmH2O/L/s) | 3.8 (1.1) | 3.6 (1.2) | 3.2 (1.1) | < 0.05 |
| R20 (cmH2O/L/s) | 2.9 (0.7) | 2.7 (0.9) | 2.5 (0.8) | < 0.05 |
| X5 (cmH2O/L/s) | −1.7 (1.0) | −1.7 (1.2) | −1.3 (0.9) | < 0.05 |
| Fres (Hz) | 16.9 (5.9) | 16.8 (6.4) | 15.1 (5.5) | < 0.05 |
| ALX (cmH2O/L/s X Hz) | 13.5 (11.0) | 13.8 (12.6) | 9.9 (9.3) | < 0.05 |
| FeNO (ppb) | 18.2 (8.4) | 17.3 (7.6) | 18.2 (8.3) | 0.88 |
| COPD Assessment Test score | 15.4 (11.6) | 17.6 (10.3) | 15.8 (11.4) | 0.11 |
| Asthma Control Questionnaire score | 6.0 (5.2) | 6.4 (5.9) | 7.5 (5.6) | 0.18 |
| Adherence Starts with Knowledge–12 score | 25.1 (6.9) | 22.2 (5.5) | 22.1 (5.4) | 0.08 |
| Serum total Ig E (IU/mL) | 899.9 (913.6) | 876.9 (1057.8) | 804.9 (961.3) | 0.39 |
| Peripheral eosinophil count (/mL) | 297.5 (208.6) | 304.0 (251.3) | 281.7 (176.9) | 0.78 |
Notes: Data are presented as mean (SD). P values were determined by one-way ANOVA.
Abbreviations: FOT, forced oscillation technique; R5 and R20, respiratory system resistance at 5 Hz and 20 Hz; X5, respiratory system reactance at 5 Hz; Fres, resonant frequency; ALX, area of low reactance; FeNO, the fraction of exhaled nitric oxide; COPD, chronic obstructive pulmonary disease; Ig, immunoglobulin.