Table 2.

Incidence of local and systematic adverse reactions among vaccination group versus control group.

Type of Vaccine	Reactions/Total		RR	95% CI	I2
	Vaccination	Control
Local adverse reactions (any) to different vaccine types
Pain
Inactivated	391/3754	42/1134	2.52	1.53; 4.14	55.5
mRNA	31924/38065	5946/37519	5.39	4.26; 6.82	92.7
Vector	573/1429	209/916	3.29	0.91; 11.77	94.8
Protein Subunit	517/832	40/220	3.3	2.08; 5.3	45.1
DNA	16/1371	12/1410	1.33	0.4; 4.38	57.3
Swelling
Inactivated	21/3154	5/984	0.86	0.33; 2.20	0.0
mRNA	3843/38065	149/37519	10.6	4.52; 24.88	88.7
Vector	37/1429	13/916	2.22	0.33; 14.88	53.2
Protein Subunit	148/832	5/220	7.07	3.05; 16.37	0.0
DNA	2/1371	5/1410	0.62	0.04; 9.16	50.6
Erythema
Inactivated	30/3754	12/1134	0.62	0.33; 1.18	0.0
mRNA	2126/37650	194/37457	7.65	3.94; 14.86	93.3
Vector	22/1429	18/916	1.33	0.67; 2.65	0.0
Protein Subunit	36/832	6/220	1.47	0.65; 3.35	0.0
DNA	2/1371	4/1371	0.76	0.02; 34.5	69.5
Systemic adverse reactions (any) to different vaccine types
Fever
Inactivated	206/3754	46/1134	1.2292	0.7696; 1.9632	0.0
mRNA	3175/38365	128/37591	8.3464	3.57; 19.51	94.9
Protein Subunit	16/832	1/220	2.98	0.56; 15.85	0.0
DNA	3/1371	0/1410	2.16	0.28; 16.71	0.0
Fatigue
Inactivated	88/3754	12/1134	0.85	0.55; 1.29	0.0
mRNA	2126/38365	194/37591	1.95	1.52; 2.51	99.0
Vector	22/1429	18/916	1.90	0.55; 6.55	94.7
Protein Subunit	356/832	58/220	1.65	1.31; 2.08	0.0
DNA	2/1371	4/1410	0.30	0.06; 1.44	0.0
Headache
Inactivated	30/3154	12/984	0.97	0.45; 2.07	0.0
mRNA	2126/38365	194/37591	1.89	1.20; 2.62	98.9
Vector	22/1429	18/916	0.99	0.48; 2.05	95.2
Protein	277/832	53/220	1.36	1.06; 1.75	0.0
DNA	5/1371	5/1410	1.31	0.35; 4.95	0.0

RR risk ratios, CI confidence interval.