Table 3.
3-month outcomes according to stroke aetiology
| A. all 3-month outcomes stratified to stroke etiology | |||||
| 3-month outcome | All (N=2082)* | N missing | Stroke etiology | ||
| Competing mechanism (N=533) | Insufficient anticoagulation (N=729) | Cardioembolism despite sufficient anticoagulation (N=820) | |||
| composite outcome, N (%) | 516 (27.1%) | 176 | 125 (25.4%) | 186 (27.8%) | 205 (27.5%) |
| recurrent ischemic stroke, N (%) | 84 (4.6%) | 240 | 33 (6.8%) | 23 (3.6%) | 28 (3.9%) |
| intracranial hemorrhage, N (%) | 15 (0.8%) | 238 | 3 (0.6%) | 6 (0.9%) | 6 (0.8%) |
| all-cause death, N (%) | 434 (22.8%) | 177 | 93 (18.9%) | 164 (24.5%) | 177 (23.8%) |
| mRS ≥3, N (%) | 1,081 (56.7%) | 177 | 258 (52.5%) | 421 (62.9%) | 402 (54.0%) |
| B. Association of stroke etiology with the primary and secondary endpoint | ||||||||||||
| Stroke etiology | Composite outcome | Recurrent ischemic stroke | ||||||||||
| unadjusted | adjusted† | unadjusted | adjusted† | |||||||||
| OR [95%CI] | p value | N events/ total N in model | aOR [95%-CI] | p value | N events/ total N in model | OR [95%-CI] | p value | N events/ total N in model | aOR [95%-CI] | p value | N events/ total N in model | |
| competing stroke mechanism | 0.90 (0.69 to 1.16) | 0.4 | 516/1906 | 1.18 (0.83 to 1.66) | 0.363 | 473/1773 | 1.80 (1.07 to 3.02) | 0.026 | 84/1842 | 1.83 (1.05 to 3.20) | 0.034 | 77/1697 |
| insufficient anticoagulation | 1.02 (0.81 to 1.28) | 0.891 | 0.93 (0.68 to 1.27) | 0.648 | 0.91 (0.52 to 1.60) | 0.751 | 0.99 (0.55 to 1.79) | 0.968 | ||||
| cardioembolism despite sufficient anticoagulation | (reference) | (reference) | (reference) | (reference) | ||||||||
*Adjusted for age, sex, hypertension, diabetes, ischaemic heart disease, dyslipidaemia, renal impairment, prior ischaemic stroke, intracranial haemorrhage, current smoking and active malignancy.
†3-month outcomes not collected in the centres Berlin, Heidelberg and Mainz.
aOR, adjusted OR; mRS, modified Rankin Scale.