Table 2.
Multiple linear regression of social cognition on each of the 18 potential covariates adjusting for age, sex, education, race, and indicator of new vs. old cohort
| Covariate | CDR level | Coef** (95% CI) | P* |
|---|---|---|---|
| Clinical Dementia Rating (CDR) global stage | CDR = 0.5 (ref: CDR = 0) |
−0.21 (−0.34, −0.07) | <0.001 |
| CDR ≥ 1 (ref: CDR = 0) |
−0.42 (−0.85, 0.01) | 0.056 | |
| CDR Judgment and Problem Solving | CDR Judgment and Problem Solving = 0.5 (ref: CDR Judgment and Problem Solving = 0) |
−0.37 (−0.53, −0.22) | <0.001 |
| CDR Judgment and Problem Solving ≥ 1 (ref: CDR Judgment and Problem Solving = 0) |
−0.63 (−0.95, −0.30) | <0.001 | |
| CDR Memory | CDR Memory = 0.5 (ref: CDR Memory = 0) |
−0.17 (−0.30, −0.03) | 0.018 |
| CDR Memory ≥ 1 (ref: CDR Memory = 0) |
−0.52 (−0.81, −0.23) | <0.001 | |
| CDR Orientation | CDR Orientation = 0.5 (ref: CDR Orientation = 0) |
−0.09 (−0.30, 0.13) | 0.415 |
| CDR Orientation ≥ 1 (ref: CDR Orientation = 0) |
−0.08 (−0.43, 0.28) | 0.665 | |
| CDR Community Affairs | CDR Community Affairs = 0.5 (ref: CDR Community Affairs = 0) |
−0.62 (−1.03, −0.22) | 0.003 |
| CDR Community Affairs ≥ 1 (ref: CDR Community Affairs = 0) |
−0.43 (−0.88, 0.02) | 0.059 | |
| CDR Home and Hobbies | CDR Home and Hobbies = 0.5 (ref: CDR Home and Hobbies = 0) |
−0.47 (−0.71, −0.23) | <0.001 |
| CDR Home and Hobbies ≥ 1 (ref: CDR Home and Hobbies = 0) |
−0.34 (−0.84, 0.16) | 0.183 | |
| CDR Personal Care | CDR Personal Care ≥ 1 (ref: CDR Personal Care = 0) |
−0.24 (−1.23, 0.75) | 0.632 |
| CDR Sum of Boxes | −0.11 (−0.16, −0.05) | <0.001 | |
| MMSE | 0.07 (0.05, 0.09) | <0.001 | |
| WTAR | 0.02 (0.01, 0.02) | <0.001 | |
| GAD-7 | −0.02 (−0.03, −0.004) | 0.015 | |
| mCES-D | −0.03 (−0.05, −0.01) | 0.012 | |
| Subjective Cognitive Complaints | −0.02 (−0.03, −0.001) | 0.037 | |
| Neuropsychological domain composite scores | Attention | 0.16 (0.10, 0.22) | <0.001 |
| Executive | 0.36 (0.29, 0.42) | <0.001 | |
| Language | 0.36 (0.29, 0.43) | 0.001 | |
| Memory | 0.16 (0.11, 0.21) | <0.001 | |
| Visuospatial | 0.26 (0.19, 0.32) | <0.001 | |
*
The Bonferroni corrected alpha level is 0.05/18= 0.003. The p-values are derived from t test, and the df = N - # of tests, where N is the total sample size of each variables (N varies as some variables have missingness).
**
Unstandardized coefficient
Abbreviations: MMSE (Mini-mental Status Exam), WTAR (Wechsler Test of Adult Reading), GAD-7 (Generalized Anxiety Disorder brief scale), mCES-D (modified Center for Epidemiological Studies-Depression scale)