. Author manuscript; available in PMC: 2023 Mar 15.

Published in final edited form as: Alzheimer Dis Assoc Disord. 2022 Mar 15;36(2):103–110. doi: 10.1097/WAD.0000000000000497

Table 4.

Association between individual-level characteristics and MCI reclassifycation from old (5-domain) to new (6-domain) MCI definition

Main covariate^*	Y = Normal to MCI (n = 43) vs. MCI to MCI (n =260)		Y = Normal to MCI (n = 43) vs. Normal to Normal (n = 450)
Main covariate^*	OR (95% CI)	P	OR (95% CI)	P
Female (ref: male)	0.65 (0.33,1.27)	0.202	0.88 (0.47,1.68)	0.698
Education > High School (ref: <=High School)	1.64 (0.80,3.60)	0.191	1.57 (0.79,3.37)	0.220
Race = White (ref: non-white)	2.01 (0.65,8.85)	0.281	0.27 (0.07,1.26)	0.059
CDR > 0 (ref: CDR = 0)	0.88 (0.76,0.98)	0.999	2.10 (0.75,5.05)	0.122
CDR Memory > 0 (ref: CDR = 0)	0.83 (0.30,2.02)	0.707	2.10 (0.75,5.05)	0.122
CDR Orientation > 0 (ref: CDR = 0)	1.21 (0.18,4.90)	0.812	2.52 (0.37,10.38)	0.252
CDR Home and Hobbies > 0 (ref: CDR = 0)	1.62 (0.34,5.72)	0.488	9.86 (1.80,50.11)	0.005
CDR Sum of Boxes	0.68 (0.23,1.35)	0.370	1.79 (0.64,4.10)	0.203
MMSE	1.33 (1.09,1.66)	0.009	0.94 (0.78,1.16)	0.547
WTAR	1.02 (0.99,1.05)	0.132	0.97 (0.94,1.00)	0.032
GAD7	1.02 (0.93,1.12)	0.619	1.12 (1.02,1.23)	0.013
mCES-D	1.00 (0.88,1.13)	0.986	1.11 (0.99,1.24)	0.057
Subjective Cognitive Complaints	0.99 (0.86,1.11)	0.843	1.11 (0.98,1.24)	0.091

Adjusting covariates in each of the 13 logistic regression models include age and new vs. old cohort indicator.The p-values are derived from Z test.

Abbreviations: MMSE (Mini-mental Status Exam), WTAR (Wechsler Test of Adult Reading), GAD-7 (Generalized Anxiety Disorder brief scale), mCES-D (modified Center for Epidemiological Studies-Depression scale)