Table 2.

Proteomic studies on serum from patients with uveal melanoma.

Year	Study	Platform	UM Sample Size	Differentially expressed proteins	Control group
2012	Suesskind et al.	ELISA (1 protein)	188	GDF-15	Healthy controls
2002	Schaller et al.	ELISA (1 protein)	137	MIA	Primary vs metastasis
2005	Reiniger et al.	ELISA (1 protein)	305	MIA	Primary vs metastasis
2006	Reiniger et al.	ELISA (1 protein)	27	Osteopontin	Healthy controls
2009	Haritoglou et al.	ELISA (2 protein)	32	Osteopontin, MIA	Primary vs metastasis
2017	Shi, et al.	Magnetic bead capture, MALDI-TOF MS	18	Fibrinogen	Healthy controls
2007	Song, et al.	Multiplex ELISA (7 proteins)	48	Osteopontin, MIA, HSP7	Healthy controls

Abbreviations: MALDI-TOF MS= matrix-assisted laser desorption/ionization time-of-flight mass spectrometry