Table 3.

Proteomic studies on aqueous humor and vitreous in eyes with uveal melanoma.

Year	Study	Platform	Tissue	UM Sample Size	Differentially expressed proteins	Control group
2020	Chen et al.	Multiplex ELISA (9 proteins)	AH	18	VEGF-A, PLGF	Before and after brachytherapy
2012	Lee et al.	Multiplex ELISA (12 proteins)	AH	20	IL-6, IL-8, IFN-g, MCP-1, IL-2, IL-10, TNF-a	Before and after brachytherapy
2003	Missotten et al.	SELDI-TOF MS	AH	24	Two proteins (4543.43 and 6853.30 kDa)	Age matched healthy controls
2019	Wierenga et al.	Multiplex ELISA (92 proteins)	AH	108	Galectin-9, TRAIL, Fas-L, ADA, CD244, CD40, MCP-3, PD-L1	Prognostic biomarkers, no controls
2017	Usui et al.	Cytometric bead array (35 proteins)	AH	13	Angiogenin, IL-8, MCP-1	Benign pigmented tumors
2010	Ly et al.	Multiplex bead array (15 proteins)	AH	37	IL-6, MCP-1, MIF, bFGF, RANTES, GM-CSF, VEGF, ICAM-11, VCAM-1, IP-10	CEIOL healthy controls
2018	Cheng et al.	Multiplex bead array (10 proteins)	AH	38	Primary Tumor Cell Culture	CEIOL healthy controls
2020	Midena et al.	Multiplex ELISA (8 proteins)	AH	35	IL-6, IL-8, RANTES, EGF, bFGF, MIF, MCP	CEIOL healthy controls
2021	Velez, et al.	Multiplex ELISA (1,000 proteins)	Vitreous and plasma	19	HGF, HGFR/c-Met, SCFR/c-Kit, Autotaxin, Arginase-1, and KLK7	GEP/PRAME status, no controls
2012	Dunavoelgyi et al.	Multiplex bead array	Vitreous and AH	34	Flt-3 ligand, IL-1a, IL-6, IL-7 IL-8, (IFN-g IP-10), MCP-1, MIP-1a, PDGF-AA, VEGF, RANTES	Vitreomacular traction
2012	Nagarkatti-Gude et al.	Multiplex bead array (27 proteins)	Vitreous	33	IL-1ra, IL-6, IL-8, IP-10, MCP-1, MIP-1a, MIP-1b, TNF-a, and RANTES	Healthy eyes

Abbreviations: SELDI-TOF MS: surface-enhanced laser desorption/ionization time-of-flight mass spectrometry