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. Author manuscript; available in PMC: 2022 Oct 11.
Published in final edited form as: Nat Biomed Eng. 2022 Apr 11;6(5):559–568. doi: 10.1038/s41551-022-00876-4

Fig. 1 |. Clinical Cerenkov Fiberscope setup with lightproof enclosure for patient imaging.

Fig. 1 |

Cerenkov luminescence is weak but measurable light emanating from alpha- or beta-emitting radionuclides used in nuclear imaging and therapy. After receiving a radiotracer, the patient is placed inside the lightproof enclosure for imaging for up to 15 minutes. The camera is placed outside of the enclosure and connected with relay optics at the proximal end of the bundle (inside the box) in addition to the fiberscope and a fast f~0.95 lens, the Cerenkov image from the patient can be recorded outside of the enclosure. Inside the enclosure the fiberscope can easily be positioned to the correct orientation to the patient with the three-axis articulating arm as well as shielded with a cerrobend baffle (Extended Data Fig. 1). As tissue highly absorbs and scatters ultraviolet and blue weighted light, the majority of the emitted CLI will be in the red part of the visible spectrum11.