Major Resources Table.

In order to allow validation and replication of experiments, all essential research materials listed in the Methods should be included in the Major Resources Table below. Authors are encouraged to use public repositories for protocols, data, code, and other materials and provide persistent identifiers and/or links to repositories when available. Authors may add or delete rows as needed.

Animals (in vivo studies)
Species	Vendor or Source	Background Strain	Sex	Persistent ID / URL
Mouse	Charles River	C57BL/6	M	https://www.criver.com/products-services/find-model/c57bl6-mouse?region=3611

Genetically Modified Animals
Strain	Vendor or Source	Background Strain	Other Information	Persistent ID / URL
CD4-Cre	Our laboratory (Laboratory of Mark W.Feinberg)	C57BL/6		Original Publication: 13
Klf10-flox

Antibodies
Target antigen	Vendor or Source	Catalog #	Working concentration	Persistent ID / URL
Anti-mouse IL-9	Bio X Cell	BE0181	200ug per mouse	https://bxcell.com/product/m-il-9
Mouse IgG2a isotype control	Bix X Cell	BE0085		https://bxcell.com/product/invivomab-mouse-igg2a-isotype-control-unknown-specificity
Anti-KLF10	Invitrogen	PA5-19845	1 μg/mL	https://www.thermofisher.cn/cn/en/antibody/product/KLF10-Antibody-Polyclonal/PA5-19845
Anti-IL-9	Abcam	Ab227037	1:500	https://www.abcam.com/il-9-antibody-epr23484-151-ab227037.html
Anti- KLF10	Abcam	Ab73537	1 μg/ml	https://www.abcam.com/klf10-antibody-ab73537.html
Anti-KLF10	Santa Cruz Biotechnology	sc-130408	1:200	https://www.scbt.com/zh/p/tieg1-antibody-95-d?requestFrom=search
Anti-HDAC1	GeneTex	Gtx100513	1:100	https://www.genetex.cn/Product/Detail/HDAC1-antibody/GTX100513
Anti-CD4	Abcam	Ab183685	1:200	https://www.abcam.com/cd4-antibody-epr19514-ab183685.html
Anti-Col8a1	Abcam	Ab236653	1:200	https://www.abcam.com/col8a1-antibody-ab236653.html
Anti-PDGFRa	Thermo Scientific	MA541209	1:200	https://www.thermofisher.cn/cn/en/antibody/product/PDGFRA-Antibody-clone-JF104-6-Recombinant-Monoclonal/MA5-41209
Anti-Col1a1	Novus Biologicals	NBP1-30054	1:250	https://www.novusbio.com/products/collagen-i-alpha-1-antibody_nbp1-30054
Anti-aSMA	Sigma-Aldrich	A5228	1:500	https://www.sigmaaldrich.cn/CN/en/product/sigma/a5228
Cy3 conjugated donkey anti-rat secondary antibody	Jackson ImmunoResearch Lab	712-165153	1:300	https://www.jacksonimmuno.com/catalog/products/712-165-153
Alexa 647 conjugated donkey anti-rabbit secondary antibody	Jackson ImmunoResearch Lab	711-605152	1:300	https://www.jacksonimmuno.com/catalog/products/711-605-152
Alexa 488 conjugated donkey anti-rabbit secondary antibody	Jackson ImmunoResearch Lab	711-545152	1:300	https://www.jacksonimmuno.com/catalog/products/711-545-152
4′,6-diamidino-2-phenylindole(DAPI)	BioLegend	422801	300 nM	https://www.biolegend.com/en-us/products/dapi-4-6-diamidino-2-phenylindole-dilactate-8108?GroupID=BLG2181
PE Rat anti-Mouse CD90.2 antibody	BD Biosciences	553006	1:100	https://www.bdbiosciences.com/en-us/products/reagents/flow-cytometry-reagents/research-reagents/single-color-antibodies-ruo/pe-rat-anti-mouse-cd90-2.553006
BUV563 Rat anti-Mouse CD45	BD Biosciences	612924	1:100	https://www.bdbiosciences.com/en-us/products/reagents/flow-cytometry-reagents/research-reagents/single-color-antibodies-ruo/buv563-rat-anti-mouse-cd45.612924
Pacific Blue Rat anti-Mouse CD3	BioLegend	155612	0.25 μg/test	https://www.biolegend.com/en-us/products/pacific-blue-anti-mouse-cd3e-antibody-16478?GroupID=BLG4744
PE Rat anti-Mouse F480	BioLegend	123109	0.5 μg/test	https://www.biolegend.com/en-us/products/pe-anti-mouse-f4-80-antibody-4068?GroupID=BLG5319
PE Cyanine7 Rat anti-Mouse CD4	BioLegend	100422	0.25 μg/test	https://www.biolegend.com/en-us/products/pe-cyanine7-anti-mouse-cd4-antibody-1919?GroupID=BLG4211
PerCP-Cy5.5 Rat anti-Mouse CD8	BioLegend	100734	0.5 μg/test	https://www.biolegend.com/en-us/products/percp-cyanine5-5-anti-mouse-cd8a-antibody-4255?GroupID=BLG2559
FITC Rat anti-Mouse IFNγ	eBioscience	11-7311-82	0.5 μg/test	https://www.thermofisher.cn/cn/en/antibody/product/IFN-gamma-Antibody-clone-XMG1-2-Monoclonal/11-7311-82
PE Rat anti-Mouse IL4	eBioscience	12-7041-82	0.125 μg/test	https://www.thermofisher.cn/cn/en/antibody/product/IL-4-Antibody-clone-11B11-Monoclonal/12-7041-82
APC Rat anti-Mouse IL9	BioLegend	514106	0.125 μg/test	https://www.biolegend.com/en-us/search-results/apc-anti-mouse-il-9-antibody-5980
FITC Rat anti-Mouse IL17	BioLegend	506908	0.25 μg/test	https://www.biolegend.com/en-gb/products/fitc-anti-mouse-il-17a-antibody-3534?GroupID=GROUP24
Alexa Fluor 488 Rat anti-Mouse FoxP3	eBioscience	53-5773-82	0.25 μg/test	https://www.thermofisher.cn/cn/en/antibody/product/FOXP3-Antibody-clone-FJK-16s-Monoclonal/53-5773-82

DNA/cDNA Clones
Clone Name	Sequence	Source / Repository	Persistent ID / URL

Cultured Cells
Name	Vendor or Source	Sex (F, M, or unknown)	Persistent ID / URL
Primary aortic fibroblasts	Primary cells	M
Primary T cells	Primary cells isolated from spleen of WT/TKO mice	M
HEK293T cells	CRL-3216, ATCC	Unknown	https://www.atcc.org/products/crl-3216

Data & Code Availability
Description	Source / Repository	Persistent ID / URL
Single cell RNA sequencing	GEO datasets
Bulk RNA sequencing	GEO datasets

Other
Description	Source / Repository	Persistent ID / URL
Angiotensin II	A9525, Sigma-Aldrich	https://www.sigmaaldrich.cn/CN/en/product/sigma/a9525
Osmotic mini pumps	Model 2004 and 2006, ALZET	https://www.alzet.com/products/alzet_pumps/
Recombinant mouse IL-9	409-ML, R&D System	https://www.rndsystems.com/products/recombinant-mouse-il-9-protein_409-ml
Mouse T-Activator CD3/CD28 for T-Cell expansion and activation	11452D, Gibco	https://www.thermofisher.com/order/catalog/product/11452D
Mouse Albumin ELISA Kit	ab207620, Abcam	https://www.abcam.com/mouse-albumin-elisa-kit-ab207620.html
Creatinine Assay Kit	ab65340, Abcam	https://www.abcam.com/creatinine-assay-kit-ab65340.html
Mouse KIM-1 ELISA Kit (KIM1)	ab213477, Abcam,	https://www.abcam.com/mouse-tim-1-elisa-kit-kim-1-ab213477.html
Von Kossa Stain Kit (Calcium Stain)	ab150687, Abcam	https://www.abcam.com/von-kossa-stain-kit-calcium-stain-ab150687.html
Alexa Fluor TM 488 conjugated wheat germ agglutinin (WGA)	W11261, Invitrogen	https://www.thermofisher.cn/order/catalog/product/W11261
PMA	P1585, Sigma	https://www.sigmaaldrich.cn/CN/en/product/sigma/p1585
ionomycin	I0634, Sigma Aldrich	https://www.sigmaaldrich.cn/CN/en/product/sigma/i0634
Brefeldin A	B5936, Sigma Aldrich	https://www.sigmaaldrich.cn/CN/en/product/sigma/b5936
Cytofix/Cytoperm kit	554714 BD, Biosciences	https://www.bdbiosciences.com/en-us/products/reagents/flow-cytometry-reagents/research-reagents/buffers-and-supporting-reagents-ruo/bd-cytofix-cytoperm-fixation-permeablization-kit.554714
Mouse CD4+ T Cell Isolation Kit	130-104-454, Miltenyi Biotec,	https://www.miltenyibiotec.com/JP-en/products/cd4-t-cell-isolation-kit-mouse.html?countryRedirected=1
Mouse CD3IFNε MicroBead Kit	130-094-973, Miltenyi Biotec,	https://www.miltenyibiotec.com/JP-en/products/cd3e-microbead-kit-mouse.html?countryRedirected=1#gref
CD45-Microbeads Kit	130-052-301, Miltenyi Biotec,	https://www.miltenyibiotec.com/JP-en/products/cd45-microbeads-mouse.html?countryRedirected=1#gref
anti-PE Microbeads	130-048-801, Miltenyi Biotec	https://www.miltenyibiotec.com/JP-en/products/anti-pemicrobeads.html?countryRedirected=1#gref
Lipofectamine 2000	11668019, Invitrogen	https://www.thermofisher.cn/order/catalog/product/11668019
Il9 promoter reporter	GeneCopoeia (MPRM39766-PG04; NM_008373)	https://www.genecopoeia.com/product/search/detail.php?prt=22&cid=&key=MPRM39766&type=promoter&choose=IL9
HDAC1 siRNA	s119558, Thermofisher	https://www.thermofisher.cn/order/genome-database/details/sirna/s119558?CID=&ICID=&subtype=
Non-specific siRNA	4390843, Thermofisher,	https://www.thermofisher.cn/order/catalog/product/4390843
Secrete-Pair Dual Luminescence Assay	LF032, GeneCopoeia	https://www.genecopoeia.com/product/secrete-pair/dual-luminescence-assay/
Chromatin Immunoprecipitation (ChIP) assay kit	#9003, Cell signal	https://www.cellsignal.com/products/chip-kits-reagents/enzymatic-chromatin-ip-kit-magnetic-beads/9003
SYBR Green Master Mix	GoTag PCR system, Promega M7122	https://www.promega.com.cn/products/pcr/taq-polymerase/gotaq-master-mixes/
Pierce™ Protein G Magnetic Beads	88847, Thermo Scientific	https://www.thermofisher.cn/order/catalog/product/88847
Fluo-8 No Wash Calcium Assay kit	ab112129, Abcam,	https://www.abcam.com/fluo-8-calcium-fluxassay-kit-no-wash-ab112129.html