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. 2022 May 16;10:862353. doi: 10.3389/fbioe.2022.862353

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Copyright © 2022 Zhou, Han, Chen, Zhang, Zhang, Wang, Liu and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cortical effect of ENS on theta activity. (A,B) Multiple-channel EEG data with theta band filtered at baseline and ENS activation. Representation of time–frequency domain spectrogram (4–8 Hz) at baseline (C) and ENS therapy (D). (E) Topographic power spectral density maps in the theta (4–8 Hz) frequency band. (F) Theta oscillations increased significantly in the frontal region, tested using a repeated-measures two-way ANOVA with post hoc Bonferroni tests. *p < 0.05.