Table 3.

Main results on non-outcome variables.

	ITT analyses, first 72 hours post-ROSC			Exploratory ITT analyses, 10-day follow-up			Additional presentation a
Hemodynamic support and related variables b	Control group	Steroids group	P-value	Control group	Steroids group	P-value	Figures S11–S18
Vasopressor infusion rate EMM (95% CI), μg/kg/min c	0.30 (0.16–0.55)	0.31 (0.18–0.52)	0.89	0.18 (0.11–0.29)	0.16 (0.10–0.27)	0.78	Figure 2B
Fluid balance, EMM (95% CI), mL	927 (–93 to 1948)	2125 (1306–2944)	0.01	1071 (408–1735)	1652 (1048–2257)	0.07	Figure S11
Arterial blood lactate, EMM (95% CI), mmol/L	4.5 (1.7–7.3)	6.2 (3.8–8.6)	0.20	2.9 (0.4–5.4)	5.7 (3.5–7.9)	0.03	Figure S12
Arterial blood pH, EMM (95% CI)	7.36 (7.32–7.41)	7.31 (7.27–7.35)	0.004	7.35 (7.30–7.40)	7.34 (7.28–7.39)	0.69	Figure S18
	ITT analysis, at 12 hours post-ROSC			ITT analysis, at 72 hours post- ROSC
	Control group	Steroids group	P-value	Control group	Steroids group	P-value
Cerebral autoregulation (by NIRS) adequate, d no./total no. (%) e	5/14 (35.7)	6/15 (40.0)	>0.99	6/14 (42.9)	4/11 (36.4)	>0.99	Table S4
	ITT analysis, 60-day follow-up
	Control group	Steroids group	P-value
Shock reversal in patients with PRS, no./total no. (%) f	16/49 (32.7)	16/43 (37.2)	0.68				NA
Days to first cessation of vasopressors, median (IQR); max g	2.0 (1.3-4.8); 9.0	3.5 (3.0-6.0); 8.0	0.18				NA
	Exploratory analysis, first 72 hours post-ROSC						Additional presentation a
	Control group	Steroids group	P-value				Supplemental Results and Figure S19
Mean systemic filling pressure, EMM (95% CI),mmHg h	20.2 (18.9–21.6)	20.0 (18.1–22.0)	0.86
Cardiac pump performance, EMM (95% CI), fraction of unity h	0.51 (0.47–0.55)	0.46 (0.42–0.50)	0.10
Systemic vascular resistance, EMM (95% CI), dynes * s/cm5h	1131 (1012–1248)	1113 (993–1232)	0.83
	Control group	Steroids group	P-value
Ventilator free days, median (IQR), max. i	0.0 (0.0-2.0), 58.0	0.0 (0.0-5.0), 53.0	0.77				NA
Length of hospital stay, days – median (IQR); max.	7.5 (0.9-32.5); 218.0	4.5 (0.7-41.3); 147.0	0.25				Table S8j

ITT, intention to treat; ROSC, return of spontaneous circulation, EMM, estimated marginal mean (by linear mixed-model analyses; see also.

Statistical Analysis); CI, confidence interval; NIRS, near-infrared spectroscopy; BS, broad spectrum; PRS, postresuscitation shock. NA, not applicable. P-values corresponding to ≥2 consecutive comparisons were subjected to the Bonferroni correction.

^aThis column cites mainly supplemental Figures and Tables with detailed reporting of the results of the ITT analyses.

^bRanges of % missing follow-up datapoints through day 10 post-ROSC for the presented variables: control group, 2.2–13.4%; steroids group, 3.0–13.8%; see Supplement for further details.

^cCalculated as the sum of the infusion rates of norepinephrine (in μg/kg/min), dopamine/2 (in μg/kg/min), and epinephrine (in μg/kg/min).⁴⁰

^dCerebral autoregulation was defined as adequate according to the following criterion: Pearson correlation coefficient between mean arterial pressure and prefrontal cortex tissue oxygenation index of <0.3;³⁴ see Methods and Supplemental Methods for further details.

^eNo. of patients with available data, ITT analysis at 12 hours post-ROSC, control group, 14; steroids group, 15; ITT analysis at 72 hours post-ROSC, control group, 14; steroids group, 11.

^fDefined as maintenance of a mean arterial pressure of >70 mmHg without any vasopressor support for a minimum of 24 hours.

^gVariable pertains solely to patients who had PRS followed by shock reversal.

^hFormulas of determination are presented in the Supplement; data originate from all patients who received cardiac output monitoring. (control group, 32; steroids group, 27); a cardiac pump performance of 1.00 is considered to reflect normal heart function.³⁹

ⁱNo. of patients with available data, ITT analysis, control group, 54; steroids group, 46.

^jSupplemental Table S8 displays additional details on the length of intensive/coronary care unit stay.