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. 2022 May 16;12:850546. doi: 10.3389/fonc.2022.850546

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Copyright © 2022 Adhikari, Macauley, Johnson, Connolly, Coleman and Heiland

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluating TME cytokine levels. (A) Cytokine levels denoted as pg/100 μg of tumor lysate for Interferonγ, tumor necrosis factorα, IL-2, and Keratinocyte Chemoattractant/human Growth-Regulated Oncogene. (B) Cytokine levels for IL-5, IL-4, and IL-10 denoted as pg/100 μg of tumor lysate. p values from Student’s t-test are denoted to signify the statistical differences between the control and treated tumors.