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. 2022 May 16;12:850546. doi: 10.3389/fonc.2022.850546

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Copyright © 2022 Adhikari, Macauley, Johnson, Connolly, Coleman and Heiland

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of responders and non-responders based on CD4 Interferonγ expression levels. (A) Tumor weight data in grams for two groups of ITI-1001-treated tumors based on the two populations of CD4 Interferonγ high and low levels observed in Figure 3B . (B) Unbiased correlation plot between tumor weight and CD4 Interferonγ+ samples. Correlation coefficient r-(-0.71). (C) Evaluating the differences between the responders and non-responders for T-cell population. (D) Evaluating the differences between the responders and non-responders for activated CD8 and CD4 T cells using IFNγ+ and TNFα+ expression. All the populations are denoted as cell numbers per gram of tumor. p values from Student’s t-test are denoted to signify the statistical differences between responders and non-responders.