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. 2022 May 16;13:900623. doi: 10.3389/fphar.2022.900623

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Copyright © 2022 Yelshanskaya and Sobolevsky.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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S1-S4 sites. (A–B), Side (A) and top (B) views of the TRPV1 tetramer (gray; PDB ID: 7LQY) with the S1-S4 top (12) and base (13) sites illustrated by ligands in red and green, respectively. Rectangles indicate the regions expanded in close-up views. (C–F) Close-up views of the S1-S4 top site in TRPV3 with bound 2-APB (C, PDB ID: 6DVZ) and S1-S4 base site in TRPV6 with bound 2-APB-Br (D, PDB ID: 6D7V), in TRPV3 with bound osthole (E, PDB ID: 7RAS), and in TRPV5 with bound ZINC17988990 (F, PDB ID: 6PBE). Residues contributing to ligand binding are shown in sticks. The chemical structures of the corresponding ligands are shown above the close-up views.