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. 2022 Mar 4;15(2):183–193. doi: 10.21053/ceo.2021.02215

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Copyright © 2022 by Korean Society of Otorhinolaryngology-Head and Neck Surgery

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2. — Association of immune signatures with the thyroid differentiation score (TDS) in advanced papillary thyroid cancer (PTC). (A) The immune landscape of PTC using the immune signature of xCell. The immune subtype based on the immune score was represented as immunehot (n=35), immune-intermediate (n=107), and immune-cold (n=140). (B) The TDS across three immune subtypes. (C) Heatmap sorted by TDS and expression of the top 20 genes that showed high correlations with the TDS. (D) Boxplots showing the major immune-checkpoint inhibitors, including CTLA4, IDO1, LAG3, and PDCD1. (E) Hub gene discovery through network module analysis for each immune subtype. ECI, extracapsular invasion; ETE, extrathyroidal extension; C_LNM, central lymph node metastasis; L_LNM, lateral lymph node metastasis; LVI, lymphovascular invasion; EMT, epithelial-mesenchymal transition.