FIGURE 2.

The neuropathological hallmarks of Alzheimer’s disease: formation of amyloid-beta plaques, formation of neurofibrillary tangles, miRNA deregulation, mitochondrial dysfunction, neuroinflammation and therapeutic targets such as BACE inhibitors and Inhibition of γ secretase, stabilization of Tau protein, influence on serotonin and histamine transmission, maintains normal levels of ATP in mitochondria and maintains enzyme activities in mitochondria, microglial activation inhibitors and regulation of specific miRNAs.