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. 2022 May 16;13:878989. doi: 10.3389/fimmu.2022.878989

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Copyright © 2022 Pietzsch, Körholz, Boschann, Sergon, Dorjbal, Yee, Gilly, Kämmerer, Paul, Kastl, Laass, Berner, Jacobsen, Roesler, Aust, Lee-Kirsch, Snow and Schuetz

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathology and immunohistochemistry of a squamous cell carcinoma of the anal canal in patient II.2. (A) Colorectal biopsy in H&E staining: left side colorectal mucosa, right side squamous cell carcinoma. (B) Anal squamous cell carcinoma in H&E staining with higher magnification with cellular atypia and dyskeratoses. (C) Anal squamous cell carcinoma showing positive p16 immunohistochemical staining of the tumor cells as a surrogate marker for HPV-infection in 7x magnification and (D) in 10.6x magnification. HPV, human papilloma virus.