Figure 5.

Transcriptional changes affiliated with CA1 neurons in RML infected mice at 150 dpi. Enrichr was used to identify enriched gene ontologies for CA1 neuron affiliated transcripts that were (A) increased and (B) decreased during RML disease. Enriched transcription factors were also identified for (C) increased and (D) decreased transcripts. (E) STRING was used to construct a protein-protein interaction network of all 123 prion altered CA1 neuron transcripts. (F) Heatmaps were used to visualize magnitude of change, expressed as log₂ fold-changes at each timepoint for notable CA1 neuron transcripts that were categorized as related to synaptic plasticity, the neuroendocrine system, dendritic spines, neurogenesis, cilia, stress response, and metabolism.