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. 2022 May 16;16:918811. doi: 10.3389/fnins.2022.918811

Figure 6.

Figure 6

Transcriptional changes affiliated with thalamus neurons in RML infected mice at 150 dpi. Enrichr was used to identify enriched gene ontologies for thalamus neuron affiliated transcripts that were (A) increased and (B) decreased during RML disease. Enriched transcription factors were also identified for (C) increased and (D) decreased transcripts. (E) STRING was used to construct a protein-protein interaction network of the 366 prion altered thalamus neuron transcripts. (F) Heatmaps were used to visualize magnitude of change, expressed as log2 fold-changes at each timepoint for notable thalamus neuron transcripts that were categorized as related to synaptic transmission, calcium transport, axon guidance, actin cytoskeleton, potassium transport, response to calcium, and neuron death.