Figure 8.

Transcriptional changes affiliated with astrocytes in the CA1 and thalamus of RML infected mice. Enrichr was used to identify enriched gene ontologies for astrocyte affiliated transcripts that were (A) increased in the CA1, (B) increased in the thalamus, (C) decreased in the CA1, and (D) decreased in the thalamus. (E) STRING was used to construct a protein-protein interaction network of the 24 astrocyte transcripts that were commonly prion altered in the CA1 and thalamus. (F) A heatmap was used to visualize magnitude of change, expressed as log₂ fold-changes at each timepoint for the common astrocyte transcripts.