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. 2022 May 16;13:873925. doi: 10.3389/fneur.2022.873925

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Copyright © 2022 Vignatelli, Baccari, Belotti, Zenesini, Baldin, Calandra-Buonaura, Cortelli, Descovich, Giannini, Guarino, Loddo, Nassetti, Sambati, Scaglione, Trombetti, D'Alessandro and Nonino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The study analysis plan of the study is according to the three aims. Aim 1—Healthcare services change: interrupted time-series (ITS) design applied to the four cohorts (PD, AP, VP, and controls) from July 1, 2019, to September 30, 2020. Aim 2—Impact analysis: historical cohort design applied to the three cohorts comparing the period March to September 2020 with the same period of 2019. Aim 3—Prognostic analysis: historical cohort design applied to the PD cohort from June 1, 2020, to December 31, 2020. The absolute number of SARS-CoV-2 infected people is reported in orange color in the time scale.