Table 1.

Outcome measures and corresponding codes of identification for each aim.

Aim	Outcome measure	Codes
1. Healthcare services change	Any outpatient visit	Any visit recorded in the outpatient specialist services database
	Any neurologic outpatient visit	Any neurologic visit recorded in the outpatient specialist services database
	Any outpatient physical therapy evaluation or treatment	Any physical therapy visit or activity recorded in the outpatient specialist services database
	Any test	Any test recorded in the outpatient specialist services database
	Any non-urgent hospital admission	Any scheduled admission recorded in the hospital discharge administrative database
	Any drug prescriptiona	Any prescription recorded in the drug prescription databases
	Parkinson's disease drug prescriptiona	ATC codes: N04BA02, N04BA03 and N04BA05 for Levodopa; N04BC04, N04BC05, N04BC01 and N04BC09 for dopamine agonists; N04BD01, N04BD02 and N04BD03 for MAO inhibitors
2. Impact analysis	Any urgent hospital admission	Any urgent admission recorded in the hospital discharge administrative database
	Hospital admissions for major injuries	ICD-9-CM codes: 800–829 (fracture of skull/of spine and trunk/of upper and lower limb); 850–854 (intracranial injury excluding those with skull fracture); 717 (internal derangement of knee); 920 (contusion of face, scalp, and neck except eye(s)); 905.2–905.4 (late effect of fracture of neck of femur/of lower extremities); 733.13 (pathologic fracture of vertebrae); 922.31 (contusion of back); 924.01 (contusion of hip); 959.11–959.12 (other injury of chest wall/of abdomen); 959.19 (other injury of other sites of trunk)
	Hospital admissions for infectionsb	ICD-9-CM codes: 480–486, 466, 507 (pneumonia); 038 (septicaemia); 595 (cystitis); 707 (decubitus)
	Hospital admissions for gastro-intestinal events	ICD-9-CM codes: 560 (intestinal obstruction); 562 (diverticular disease); 567 (peritonitis); 569 (intestinal or peritoneal abscess/intestinal perforation/intestinal fistula); 578 (diverticular bleeding)
	Hospital admissions for thromboembolic events	ICD-9-CM codes: 451 (deep vein thrombosis); 415 (pulmonary embolism)
	Hospital admissions for psychiatric events	ICD-9-CM codes: 290–299, 300–315.9 (psychosis)
	Hospital admissions for hypotension/syncope	ICD-9-CM codes: 780.2 (hypotension); 458 (syncope)
	Hospital admissions for acute cardiac and cerebrovascular events	ICD-9-CM codes: 410–411, 428 (acute cardiac events); 430–434, 436 (acute cerebrovascular events).
3. Prognostic analysis	All categories related to aim 2 were merged as composite any PD related major clinical outcome	Same as above

^aCalculated as days of therapy on the basis of Defined Daily Doses.

^bDischarge codes related to COVID-19 events were excluded (079.82; 480.3).