Table 4.

Monthly rates (×1,000), as mean of March-September period in 2019 (control period) and 2020 (first epidemic bout period and flattening of the epidemic curve period), in the ParkLink Bologna cohorts and in the control cohort.

Outcomes	PD	AP	VP	Control	PD	AP	VP	Control	PD	AP	VP	Control
	2019 monthly rate × 1,000				2020 monthly rate × 1,000				2020 vs. 2019 rate ratios (95% CI)
Any urgent hospital admission	13.4	23	17.3	10.7	17.6	33.5	9.3	11.6	1.3 (1–1.8)	1.4 (0.70–3.1)	0.54 (0.17–1.6)	1.1 (0.98–1.2)
Any disease-specific hospital admission	8.8	16.9	23.1	9.2	18.4	22.9	10.9	9.9	2.1 (1.5–3.0)	1.4 (0.56–3.3)	0.47 (0.16–1.2)	1.1 (0.96–1.2)
Major injuries	1.9	-	13	1.9	5.7	3.5	3.1	1.7	3.0 (1.5–6.2)	-	0.24 (0.03–1.2)	0.93 (0.72–1.2)
Infections	1.5	7.7	1.4	1.8	4.9	12.3	4.7	2.3	3.3 (1.5–7.2)	1.6 (0.4–6.4)	3.2 (0.3–169.5)	1.3 (0.99–1.6)
Gastro-intestinal events	1.1	1.5	4.3	0.49	0.39	-	-	0.73	0.35 (0.07–1.7)	-	-	1.5 (0.94-2.3)
Psychiatric events	2.3	7.7	4.3	1.4	3.1	1.8	3.1	1.2	1.4 (0.66–2.9)	0.23 (0.05–2.1)	0.72 (0.06–6.3)	0.91 (0.67–1.2)
Hypotension	0.56	-	-	0.48	0.98	5.3	-	0.33	1.7 (0.41–7.3)	-	-	0.69 (0.40–1.2)
Thromboembolic events	-	-	-	0.12	0.20	-	-	0.21	-	-	-	1.7 (0.69-4.0)
Coronary artery disease	0.56	-	1.4	0.56	0.59	1.8	1.6	0.51	1.0 (0.21–5.2)	-	1.08 (0.01–84.5)	0.91 (0.56–1.5)
Heart failure	0.56	1.5	1.4	1.5	1.8	1.8	6.2	1.8	3.1 (0.85–11.5)	1.15 (0.01–30.1)	4.3 (0.43–212)	1.2 (0.90–1.6)
Ischaemic stroke	0.19	-	-	0.81	0.59	-	-	0.81	3.1 (0.32–30.0)	-	-	1.0 (0.68–1.5)
Haemorrhagic stroke	0.19	-	-	0.22	0.20	-	-	0.27	1.0 (0.07–16.6)	-	-	1.2 (0.61–2.5)

The last three columns show rate ratios comparing 2020 monthly rates to 2019 monthly rates within each cohort. In bold statistically significant rate ratios.

PD, Parkinson's disease; AP, Atypical parkinsonism; VP, Vascular parkinsonism.