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. 2022 May 16;13:871927. doi: 10.3389/fgene.2022.871927

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Copyright © 2022 Pitirri, Durham, Romano, Santos, Coupe, Zheng, Chen, Kawasaki, Jabs, Richtsmeier, Wu and Motch Perrine.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ERK pathway activation in the lower jaw of Fgfr2c ^+/+ and Fgfr2c ^C342Y/+ embryos at E15.5. Immunofluorescence for p-ERK1/2 in coronal sections of Fgfr2c ^+/+ (top) and Fgfr2c ^C342Y/+ (bottom) embryos at E15.5. Anterior, Mid 1, Mid 2, and Posterior indicate the regions of the lower jaw identified in Figure 1. Images in MB ROI column show higher magnification of the boxed areas in Mid 2. Arrows mark the locations of the perichondrium of MC. I, incisor; MB, mandible; MC, Meckel’s cartilage; T, tongue. n = 3 per genotype with at least 4 images per individual being analyzed. Scale = 100 µm.