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. 2022 May 30;8(2):00528-2021. doi: 10.1183/23120541.00528-2021

FIGURE 2.

FIGURE 2

Time trends in various aspects of asthma including current wheeze, wheeze ever, nocturnal cough, severe asthma and asthma ever through the International Study of Asthma and Allergies in Childhood (ISAAC) Phase I and Phase III, and the Global Asthma Network (GAN) Phase I, in the two age groups of children. #: severe asthma is defined as more than four attacks of wheezing in previous 12 months or wheeze affecting sleep or speech in previous 12 months. *: p<0.05; **: p<0.01; ***: p<0.001 when ISAAC Phase I compared to ISAAC Phase II. ¶¶¶: p<0.001 when ISAAC Phase III compared to GAN Phase I.