Table 4.
Responsiveness of LCQ scores: LCQ total from baseline to week 4 by PGIC category and awake cough frequency.
| Category | N | Baseline, mean (SD) |
Week 4, mean (SD) |
Mean score change a | Effect size b | |
|---|---|---|---|---|---|---|
| Difference | Range | |||||
| PGIC score | ||||||
| 1 or 2 | 87 | 12.0 (2.94) | 17.5 (2.57) | 5.6 | −4.7 to 12.3 | 1.9 |
| 3 | 78 | 11.9 (2.99) | 14.2 (2.65) | 2.3 | −2.2 to 6.7 | 0.8 |
| 4 | 61 | 11.4 (2.75) | 11.9 (2.89) | 0.5 | −3.2 to 7.0 | 0.2 |
| 5 | 5 | 9.6 (3.91) | 9.1 (3.22) | −0.6 | −1.8 to 1.3 | −0.2 |
| 6 or 7 | 4 | 12.7 (3.28) | 10.2 (3.73) | −2.6 | −4.0 to −1.9 | −0.8 |
| Awake cough frequency | ||||||
| ⩾30% reduction | 126 | 11.9 (2.74) | 16.0 (3.27) | 4.1 | −4.7 to 12.3 | 1.5 |
| <30% reduction | 102 | 11.5 (3.22) | 12.9 (3.38) | 1.3 | −4.0 to 10.2 | 0.4 |
| ⩾50% reduction | 79 | 11.7 (2.89) | 16.9 (2.94) | 5.2 | −4.7 to 12.3 | 1.8 |
| <50% reduction | 149 | 11.8 (3.01) | 13.4 (3.46) | 1.6 | −4.0 to 10.8 | 0.5 |
| ⩾70% reduction | 52 | 11.7 (2.70) | 17.5 (3.06) | 5.8 | −4.7 to 12.3 | 2.2 |
| <70% reduction | 176 | 11.8 (3.04) | 13.8 (3.39) | 2.0 | −4.0 to 10.8 | 0.7 |
| Reduction ⩾0.30 SD | 118 | 11.5 (2.70) | 15.6 (3.48) | 4.2 | −4.7 to 12.3 | 1.5 |
| Reduction <0.30 SD | 110 | 12.1 (3.21) | 13.5 (3.57) | 1.5 | −4.0 to 10.2 | 0.5 |
LCQ, Leicester Cough Questionnaire; PGIC, patient global impression of change; SD, standard deviation.
a
Calculated as week 4 − baseline.
b
Calculated as score difference/SD of baseline score.