Table 2.
- Association of measles complications with SNPs in the TLR2 gene.
| Measles complications | SNPs | Total | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs3804099 allele | rs3804100 allele | rs1816702 allele | ||||||||||
| T>T | C>T | P-value | T>T | C>T | P-value † | T>T | C>T | P-value † | ||||
| n (%) | n (%) | n (%) | n (%) | |||||||||
| Pneumonia | 8 (40) | 12 (60) | 0.11* | 13 (65) | 7 (35) | 0.76 | 5 (25) | 15 (75) | 0.13 | 20 (40) | ||
| LRTI | 3 (37.5) | 5 (62.5) | 0.25 * | 1 (12.5) | 7 (87.5) | 0.004 | 1 (12.5) | 7 (87.5) | 0.12 | 8 (16) | ||
| Diarrhea | 4 (100) | 0 (0) | 0.12 † | 3 (75) | 1 (25) | 0.64 | 4 (100) | 0 (0) | 0.02 | 4 (8) | ||
| Pneumonia + diarrhea | 2 (66.7) | 1 (33.3) | 1.0 † | 2 (66.7) | 1 (33.3) | 1.0 | 0 (0) | 3 (100) | 0.26 | 3 (6) | ||
| Diarrhea + LRTI | 7 (87.5) | 1 (12.5) | 0.06 † | 5 (62.5) | 3 (37.5) | 1.0 | 6 (75) | 2 (25) | 0.04 | 8 (16) | ||
| Pneumonia + otitis media | 2 (66.7) | 1 (33.3) | 1.0 † | 3 (100) | 0 (0) | 0.26 | 2 (66.7) | 1 (33.3) | 0.55 | 3 (6) | ||
| Myocarditis + LRTI | 1 (100) | 0 (0) | 1.0 † | 1 (100) | 0 (0) | 1.0 | 1 (100) | 0 (0) | 0.4 | 1 (2) | ||
| SSPE | 1 (100) | 0 (0) | 1.0 † | 1 (100) | 0 (0) | 1.0 | 0 (0) | 1 (100) | 1.0 | 1 (2) | ||
| Pneumothorax | 0 (0) | 1 (100) | 0.4 † | 1 (100) | 0 (0) | 1.0 | 0 (0) | 1 (100) | 1.0 | 1 (2) | ||
| Otitis media | 0 (0) | 1 (100) | 0.4 † | 0 (0) | 1 (100) | 0.4 | 1 (100) | 0 (0) | 0.4 | 1 (2) | ||
| Total | 28 (56) | 22 (44) | 30 (60) | 20 (40) | 20 (40) | 30 (60) | 50 (100) | |||||
LRTI: lower respiratory tract infection, SSPE: subacute sclerosing panencephalitis, SNPs: single nucleotide polymorphisms, TLR2: toll-like receptor -2, p<0.05 was considered significant at the 95% confidence interval (CI)
*
Chi-square test,
†
Fisher’s exact test