Table 2.
MicroRNAs revealed with causal network analysis: LR12 + TAK242-treated vs. scrambled peptide and vehicle (30% ethanol)-treated arteries. DEGs with higher expression in scrambled peptide-treated group (log2 > 2, p < 0.05) and with higher expression in LR12 + TAK242-treated group (log2 < −2, p < 0.05).
| Associated with Activated Network | DEGs (log2 > 2, p < 0.05) | DEGs (log2 < −2, p < 0.05) | DEGs (log2 < 2 or >−2, p < 0.05) |
|---|---|---|---|
| miR-205-5p | ADAM8, ADAMTS4, ARG1, CD27, CD3D, CD5, CSF2RB, CXCL8, DNAH11, DUOX2, GP1BA, GP1BB, HPSE, IL1R1, IL2RB, IL7R, KDM6B, LAG3, MMP25, NCOR2, PCDH8, PHACTR1, PPRC1, PTX3, RELT, SEMA4A, SERPINB2, STAT4, STEAP4 |
ADAMTS8, ADIPOR2, AQP11, BCAM, CAT, CEBPA, CIDEC, DHH, EIF4EBP1, HCAR1, LMO2, MYLPF, PLIN1, PLIN5, PNPLA2, PPARG, RETSAT, SEMA3G, SERPINI1, TEK, WNT11 |
CD6, CXCR5, EGR2 |
| Associated with inhibited networks | |||
| mir-515 | ADAM8, ADAMTS4, ALAS2, BCL3, CCR7, CD27, CD3D, CD69, COL6A3, CXCL8, DUOX2, ECM1, EDIL3, EGR1, FCMR, FERMT3, GP1BA, GPR84, HPSE, ICOS, IL2RB, IL7R, KDM6B, LAG3, MAP3K14, MUC13, MYC, NCOR2, PCDH8, PHACTR1, PLAGL1, PPRC1, PRDM1, PTX3, RCAN1, RNF213, SBNO2, SELP, SEMA4A, SERPINB2, SLAMF7, ST18, STAT4, STC1, TUBB1, VWF |
AGT, ALDH9A1, APOD, APOE, ASS1, BCAM, BMX, CAVIN2, CIDEC, CLEC14A, CYP4B1, DDIT4L, ECH1, EIF4EBP1, ENHO, EPHX2, HCAR1, MMD, MYH4, MYL1, OSM, OSMR, PPARG, PLIN5, PNPLA2, PON3, S100A1, SERPINI1, TCAP, TEK, TMOD4, TNNC2, TSPAN5 | CD6, CXCR5 |
| mir-153 | ADAMTS1, CD5, CD69, CSF2RB, CXCL8, DUOX2, EGR3, FCMR, GP1BA, HAS1, ICOS, IL2RB, ITGA2B, ITGB7, KDM6B, NCOR2, NFATC2, PDE4B, PHACTR1, PRDM1, RNF213, SERPINB2, ST18, STAT4, STEAP4, TEAD3, VDR |
AGT, ALDH1A1, APOD, APOE, BCAM, DHH, MYH8, MYL1, MYOT, OSM, OSMR, PLIN1, RAMP2, RETSAT, S100A1, SCD, TCAP, TNNC2, WNT11 |
|
| mir-219 | ALAS2, BCL3, BLK, CCL22, CSF2RB, CXCL8, DUOX2, FCMR, ICOS, IL2RB, IL7R, ITGA2B, NFATC2, PDE4B, PHACTR1, PLAGL1, PRDM1, PTX3, RNF213, SBNO2, STEAP4, TUBB1, VWF |
ALDH1A1, APOD, APOE, ASS1, BCAM, CAT, CAVIN2, LDHB, PPARG, MMD, MYL1, MYLPF, MYOT, OSM, PEX11A, RAMP1, TEK | EGR2, IL9R |
| mir-22 | CCL22, CCR7, DUOX2, HAS1, IL1R1, IL2RB, IL7R, ITGA2B, ITGB7, NFATC2,PTX3, RCAN1, SERPINB2, STEAP4, VDR | ALDH1A2, ASS1, BCAM, MYLPF, TNNC2 | EGR2 |