Table 3.
Transcription factors revealed with upstream network analysis: LR12 + TAK242-treated vs. contralateral femoral arteries. DEGs with higher expression in LR12 + TAK242-treated group (log2 > 2, p < 0.05) and with higher expression in contralateral femoral arteries (log2 < −2, p < 0.05).
| Associated with Activated Networks | DEGs (log2 > 2, p < 0.05) | DEGs (log2 < −2, p < 0.05) | DEGs (log2 < 2 or >−2, p < 0.05) |
|---|---|---|---|
| MYOD1 | CXCL14, MYH4, MYL1, MYLPF, MYOD1, TNNC2 | IGF1 | |
| SMARCA4 | IL7R, ITGA3, MYL1, MYLPF, TNNC2 | CNTN1, MAP1B, MFGE8, | IGF1 |
| MEF2C | MYLPF, MYOD1, MYOT | FRZB, KCNA5, | IGF1 |
| MYF6 | EGF, IL15, IL7, MYOD1, | ||
| HOXC8 | IL1R2, SLC16A3 | ||
| SPDEF | ITGA3 | TNC | COL4A2 |
| SPI1 | CD1D, CXCL14, IL18, IL1R2, IL7R | CD79B | |
| IRF1 | IL15, IL18, IL7, MMP9 | ||
| RB1 | HOMER1, MYH4, MYH8, MYL1, TCAP, TNNC2 | IGF1, COL4A2 | |
| ARNT2 | APOE, EGF, HOMER1 | ||
| SIM1 | APOE, EGF, HOMER1 | ||
| Associated with inhibited network | |||
| HDAC4 | HOMER1, MMP9, MYLK2, MYOT | CNTN1 | |
| KDM5A | HOMER1, MYH4, MYH8, MYL1, TCAP, TNNC2 | ||
| HTT | APOE, HOMER1, IL15, MYL1, MYOD1, | PRELP | COL4A2 |
| VDR | IL18, MYH8, S100A8 | COL4A2 | |