Table 4.
Transcription factors (TFs) revealed with causal network analysis: LR12 + TAK242-treated vs. contralateral femoral arteries. DEGs with higher expression in LR12 + TAK242-treated group (log2 > 2, p < 0.05) and with higher expression in contralateral femoral arteries (log2 < −2, p < 0.05).
| Associated with Activated Networks | DEGs (log2 > 2, p < 0.05) | DEGs (log2 < −2, p < 0.05) | DEGs (log2 < 2 or >−2, p < 0.05) |
|---|---|---|---|
| MYF6 | ANK1, APOE, CASQ1, EGF, HOMER1, IL15, IL18, IL7R, MYL1, MYLPF, MYOD1, MYOT, TCAP, TNNC2, TRIM63 |
AQP5, NOTCH3, TNC | IGF1 |
| MYOD1 | ANK1, APOE, CASQ1, EGF, HOMER1, IL18, IL7R, MYL1, MYLPF, MYOT, TCAP, TNNC2, TRIM63 |
AQP5, NOTCH3, TNC | IGF1 |
| NCOA4 | AMPD1, APOE, CD1D, CD247, CD3G, CYGB, DDIT4L, EGF, FGR, HABP2, ICAM3, IL15, IL1R2, IL7R, MMP9, MMRN1, MYH8, MYLPF, MYOT, MYPN, PRKCQ, S100A1, SLN, TFPI, TNNC2, XIRP2 |
ADAMTSL4, AEBP1, COL8A1, ELN, FBLN5, FRZB, KCNA5, MAP1B, MFGE8, NOTCH3, SLIT3 | IGF1, COL4A2 |
| NCOA1 | ANK1, CNKSR1, CXCL14, DOK5, EGF, HOMER1, ICAM3, IFIT1, IL15, IL18, IL1R2, IL7, IL7R, MYH4, MYH8, MYL1, MYOT, MYPN, PLIN5, STK17B, TCAP, TNNC2, TRIM63, XIRP2 |
AEBP1, AQP5, COL8A1, ELN, FBLN5, FMOD, ITGA3, MAP1B, NOTCH3, SLIT3 |
COL4A2 |
| FOXA1 | CD1D, CD247, CNKSR1, CXCL14, CYGB, DDIT4L, FGR, HOMER1, ICAM3, IFIT1, IL15, IL18, IL7, MMP9, MYH4, MYH8, MYL1, MYLPF, MYOD1, MYPN, PLIN5, PRKCQ, S100A1, STK17B, TCAP, TNNC2, XIRP2 |
ADAMTSL4, BGN, ELN, COL8A1, FBLN5, FMOD, FRZB, ITGA3, MAP1B, TNC, NOTCH3, PRELP, SLIT3 | IGF1, COL4A2, CD79B |
| SMARCC1 | CNKSR1, ICAM3, IL7R, MMP9, MYOT | ITGA3, MAP1B, NOTCH3, TNC | IGF1, CD79B COL4A2 |
| SMARCA4 | IFIT1, MYL1, MYLPF, TNNC2 | CNTN1 | IGF1 |
| HOXC8 | IL1R2, SLC16A3 | ||
| SPDEF | ITGA3, TNC | COL4A2 | |
| IRF9 | IFIT1, IL18 | ||
| Associated with inhibited networks | |||
| AHRR | CD1D, CD247, CD3G, CXCL14, HABP2, ICAM3, IFIT1, IL15, IL18, IL1R2, IL7R, MYH4, MYH8, MYL1, MYLK2, MYOT, MYPN, PLIN5, PRKCQ, STK17B, TCAP, TRIM63, XIRP2 |
AEBP1, FBLN5, FMOD, FRZB, MFGE8, NOTCH3, SLIT3 |
COL4A2 |
| HDAC3 | ANK1, CXCL14, DOK5, HABP2, IFIT1, IL15, IL18, IL7, IL7R, MYH8, MYLPF, PLIN5, S100A8, SLN, TFPI, TRIM63 |
AQP5, BGN, COL8A1, ELN, FBLN5, ITGA3, KCNA5, NOTCH3, RASL11B | IGF1, COL4A2 |
| EID1 | CNKSR1, CXCL14, CYGB, DDIT4L, DOK5, EGF, FGR, HOMER1, ICAM3, IL15, IL18, IL7, MMP9, MYH4, MYH8, MYL1, MYOT, MYPN, PLIN5, S100A8, STK17B, TMOD4, TNNC2, XIRP2 | ADAMTSL4, ADRA1D, AEBP1, AQP5, BGN, FBLN5, FRZB, KCNA5, MAP1B, NOTCH3, SLIT3, TNC | IGF1 |
| HOXA10 | APOE, CNKSR1, CXCL14, CYGB, DDIT4L, DOK5, EGF, FGR, HOMER1, ICAM3, IL15, IL18, IL7, MMP9, MYH4, MYH8, MYL1, MYOT, MYPN, PLIN5, S100A8, TK17B, TMOD4, TNNC2, XIRP2 | ADAMTSL4, ADRA1D, AEBP1, FBLN5, FRZB, KCNA5, MAP1B, NOTCH3, SLIT3, TNC | CD79B |
| MTA2 | CD1D, COL8A1, CXCL14, DOK5, ICAM3, IFIT1, IL15, IL18, IL1R2, IL7R, MMP9, MYH4, MYH8, MYL1, MYLPF, MYOD1, MYOT, PLIN5, S100A8, SLC16A3, TNNC2, TRIM63 |
AQP5, ELN, FBLN5, MAP1B, | |
| HOXA9 | ADAMDEC1, C5AR2, CNKSR1, CXCL14, CYGB, DOK5, FGR, ICAM3, IL18, IL7R, MYH4, MYH8, MYL1, MYOD1, MYOT, MYPN, PLIN5, PRKCQ, S100A8, STK17B, TNNC2, TRIM63, XIRP2 |
ADRA1D, AEBP1, FBLN5, FRZB, ITGA8, KCNA5, MAP1B, NOTCH3, SLIT3, TNC |
CD79B |
| TCF3 | CD3G, IL7R, MMP9, MYL1, MYLPF, MYOD1, STK17B, TNNC2 |
NOTCH3 | IGF1, CD79B |
| AHRR | CD247, CD3G, IL15, IL1R2, IL7R, MYLK2, MYOT, PRKCQ |
FBLN5, NOTCH3 | COL4A2 |
| AIP | ADRA1D, APOE, CD247, CD3G, IL15, IL1R2, IL7R, PLIN5, PRKCQ, S100A8 |
FBLN5, NOTCH3 | COL4A2 |
| KDM5A | HOMER1, MYH4, MYH8, MYL1, TCAP, TNNC2 | ||
| DNMT3L | CASQ1, IFIT1, S100A1, SLIT3, SLN | CD79B | |
| EHF | HOMER1, MMP9, MYH4, MYH8, MYL1, S100A8, TCAP, TFPI, TNC, TNNC2 |
NOTCH3 | IGF1 |
| HDAC4 | MYLK2, MYOT | ||
| SOX15 | MMP9, MYOD1 | ||