Table 3.
Examples of circRNAs acting as miRNA sponges and their functions in various types of cancer.
| circRNA | miRNA Target | Disease Associated | circRNA Expression | circRNA Function | References |
|---|---|---|---|---|---|
| ciRS-7 (CDR1as) | miR-7 | Several cancers including NSCLC and CRC | upregulated | oncogene | [94,115,116,117] |
| circHIPK3 | miR-7, miR-124, miR-506 | CRC, GBC, HCC | upregulated | oncogene | [118,119,120] |
| circITCH | miR-7, miR-214 | CRC, lung cancer, NPC | downregulated | tumor suppressor | [104,121,122] |
| circNT5E | miR-422a, miR-134, miR-502-5p | Glioma, NSCLC, bladder cancer | upregulated | oncogene | [123,124,125] |
| circDENND2A | miR-625-5p | Glioma | upregulated | oncogene | [126] |
| circDENND4C | miR-200b, miR-200c, miR-141-3p | Breast cancer, NSCLC, lung cancer | upregulated | oncogene | [127,128] |