Table 1.

Change of electrostatic interactions between receptor binding domain of severe acute respiratory syndrome coronavirus 2 and the angiotensin-converting enzyme 2 receptor

Types	Mutations	Electrostatic interactions
		Overall, kcal/mol	Change compared to wild type, %
Wild type	No	-39.38	0
Beta variant	T478K, P681R, and L452R	-41.26	104.8
Dela variant	T478K, P681R, L452R, and K417N	-163.82	416.0
Omicron variant	A67V, T95I, G142D, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, and L981F	-634.71	1611.8